💡 New in NARMME: TRL1 enzyme from Candida glabrata changes shape to control RNA repair, vital for fungal survival. Its absence in humans makes it a promising antifungal drug target.

📖 Read more: doi.org/10.1093/narm...

#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess

Structure of fungal tRNA ligase Trl1 with RNA reveals conserved substrate-binding principles - Nature Structural & Molecular Biology Köhler et al. present the crystal structure of fungal tRNA ligase Trl1-LIG bound to an activated RNA substrate, providing key insights into conserved substrate binding and activation, enzyme specifici...

Trl-ing Research!
#tRNA #Ligase #Trl1 #Yeast #RNA

www.nature.com/articles/s41...