Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin Chuangxinmycin (CXM) is a promising antimicrobial compound targeting bacterial tryptophanyl-tRNA synthetase (TrpRS), an essential enzyme in protein synthesis. The detailed inhibitory mechanism of CXM, particularly in clinically relevant pathogenic bacteria, is poorly understood. In this study, based on the determin

Zoom in on CXM 🔬

New #RSCChemBio study reveals how chuangxinmycin hits bacterial TrpRS enzymes—but not human ones. 10 crystal structures + MD sims = a blueprint for selective antibiotic design.

#RSCchembio #StructuralBiology #Antibiotics #TrpRS #AMR
doi.org/10.1039/D5CB...