✨ Don't miss this review from Keiji Numata in #RSCChemBio bridging molecular chemistry and macroscopic material function!

➡️ Read about the chemical diversity of post-translational modifications in silk proteins here! doi.org/10.1039/D6CB...

Comparative analysis of alkyne- and desthiobiotinylated photoaffinity probes for chemotranscriptomic profiling Understanding small molecule–RNA interactions is a crucial part in drug development and fundamental biology. Chemotranscriptomic profiling is emerging as a powerful platform to interrogate interactions of small molecules with entire transcriptomes. This technique relies on photoaffinity probes that covalently captu

📢 Out now in #RSCChemBio 📢

✨ Willem Velema and his team at Radboud University assess the suitability of desthiobiotin and alkyne modified RNA-targetting photoaffinity probes towards optimizing chemotranscriptomic profiling workflows!

➡️ Read more here! http://doi.org/10.10

Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection Broad spectrum antivirals are critical to respond rapidly to the threat posed by newly emerging RNA viruses. One potential candidate is the natural compound thapsigargin (Tg). Tg potently induces endoplasmic reticulum (ER) stress and activates the unfolded protein response (UPR). Recent studies have demonstrated th

🌿 How can natural products such as Thapsigargin (Tg) have antiviral activities against human coronaviruses?

💡 Hint: It has alot to do with the unfolded protein response pathway!

👉 Read more in this #RSCChemBio Advance Article from Che Colpitts and her team here: http://doi.org/10.10

Tuning potency for precision: the role of the G4-ligand in G4-ligand conjugated oligonucleotides targeting individual G-quadruplex DNA structures The non-B DNA secondary structure known as G-quadruplex (G4) DNA can form in gene-regulatory regions of the human genome. Organic small molecules, so called G4-ligands, which bind and stabilize G4 DNA structures, have emerged as potential therapeutic agents and as chemical probes to study the cellular functions of

📢 Have you read this #RSCChemBio Advance Article?

✨ Find out how Erik Chorell and his team tune the selectivity and strength of G4-targeting chemical probes to study the cellular functions of secondary DNA conformations.

👉 Catch the article and more like it here!

Celebrating International Women’s Day 2026 with standout women researchers at the chemistry-biology interface.
Explore our new collection: pubs.rsc.org/en/jour...
Contact us if you have a recent #RSCChemBio publications to add to this collection!
#InternationalWomensDay #WomenInScience #WomenInSTEM

📢 New Advanced Article from #RSCChemBio 👇
Warren, Taga, Kräutler et al. explore the gene repression activity of AdoRhbl in B₁₂-utilizing microorganisms, establishing its potential as a multifunctional antibiotic.
👉 Read the full story here: doi.org/10.1039/D5CB...

✨Research spotlight on targeted protein degraders: from macrocyclic peptides to nanoparticle-based delivery systems, there is a wealth and diversity of PROTACs research published in #RSCChemBio each year.
Find the highlights from 2025 on our blog now:
🔗blogs.rsc.org/cb/202...
#PROTAC #RSCChemBio

📢Latest issue of #RSCChemBio is online and #openaccess

This month's issue features a profile of our 2025 #EmergingInvestigators, late-stage peptide modifications, genome mining of the actinomycetes landscape, and much more!

👉 Get the full issue here: pubs.rsc.org/en/journals/...

graphical abstract of RSC ChemBio article "Covalent targeting of PSMD14 by Eupalinolide B induces oncoprotein degradation and apoptosis in acute promyelocytic leukemia cells"

📢New Advance Article in #RSCChemBio

Chengchao Xu, Jigang Wang, Huan Tang et al. investigate the anti-leukemic potential of Eupalinolide B (EB) using integrated chemoproteomic profiling and functional validation studies.

👉Get the full story here: doi.org/10.1039/D5CB...

We are sponsoring the RSC CBBG Forum with poster prizes from #OBC, #ChemicalScience, #RSCChemBio and #RSCMedChem!
Poster Abstract deadline 6th February, so register now!
📆6th March
📍Cardiff University
🔗www.rsc.org/events/detail/82568/2026...

⏱️"Does sod1 encode a #molecularclock?" Researchers at Baylor University investigate in this #openaccess Advance Article from #RSCChemBio

🔗Read the full story here: doi.org/10.1039/D5CB...

Double-hit approach for novel glycoconjugates combining cytoplasmic glycoengineering and selective chemistry Chemical conjugation to carrier proteins has been traditionally used to improve polysaccharides immunogenicity and to overcome the limitations of T-independent antigens, including lack of immunological memory and efficacy in infants. A double-hit approach, meaning that both polysaccharide and carrier protein belong

🦠 In their new #RSCChemBio article, Gianmarco Gasperini and his team report on their development of a novel selective conjugation strategy based on cytoplasmic protein glycoengineering!

👉 Read more about how this approach is advancing the design of glycoconjugate vaccines.

Tuning the efficiency of molecular probes via quinone methide-based in situ labeling Imaging the activities of hydrolases using molecular imaging probes can reveal underlying molecular mechanisms in the context of cells to organisms and their correlation with different pathological conditions can be used in diagnosis. Due to the nature of hydrolases, substrate-based probes can take advantage of the

✨ From our newest #RSCChemBio themed collection, Zachary Rabinowitz and Seyedeh Alaleh Anvar introduce their hydrolase-targeting probes!

📢 Read more about their use of quinone-methide chemistry towards developing and tuning these probes here: doi.org/10.1039/D5CB...

#FlourescentProbes

📢 #RSCChemBio is sponsoring two poster prizes at the EMBO-EMBL Chemical Biology Workshop 2026!

📅 8 - 11th September 2026
📍 EMBL Heidelberg, Germany
🔗 www.embl.org/about/i...

Submit your abstract by 2nd June 2026 to a part of the event!

EMBO #ChemicalBiology

#RSCPoster is happening again on March 3rd and 4th, 2026, here on LinkedIn. I am happy to be involved as subject chair for #RSCChemBio.

If you want to share some exciting research in #Chemistry and especially #ChemBio consider registering for the event:

www.rsc.org/our-events/a...
#ChemSky

Inside front cover of RSC Chemical Biology Issue 12. A large blue pill-like shape in middle with smaller pill-like shapes around, highlighting circle in middle showing various structures including green train and red stop sign.

Back cover of RSC Chemical Biology Issue 12. A large molecular image in the foreground with smaller molecular structures and a pale yellow ribbon structure in the background.

Front cover of RSC Chemical Biology issue 12. Two crabs on a beach, one crab holding a green molecule structure, second green molecule structure in bottom right corner.

#RSCChemBio Issue 12 is now online and #openaccess!
In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more!
📰Read the full issue here: pubs.rsc.org/en/journals/...

📣 Present your research at EMBL’s The Epitranscriptome (28–30 Oct)!
🧬 RSC Chem. Biol. & Molecular Omics are sponsoring poster prizes.

🗓️ Abstract deadline: 5 August – submit now!
👉 www.embl.org/about/i...
#Epitranscriptome #RSCChemBio #MolOmics #ScienceSky

Regulation of carcinogenesis through multiple zinc fingers in ZBTB20 Zinc finger (ZF) proteins regulate transcription by interacting with cis-acting elements for gene expression in response to stimuli within physiological systems. Bioinformatic studies have proposed that zinc finger and BTB (Broad complex, Tramtrack, Bric-à-brac) domain-containing protein 20 (ZBTB20) acts as

ZBTB20’s zinc fingers pack a punch 🧬Seung Jae Lee et al., show how it targets AFP & FOXO1 to regulate tumor pathways with the first biochemical proof of its DNA binding.
Read the full paper here: doi.org/10.1039/D5CB...
#ZBTB20 #ChemicalBiology #CancerResearch #RSCChemBio

Unravelling the role of key amino acid residues of the parainfluenza fusion peptide in membrane fusion Parainfluenza viruses enter host cells by fusing their envelope with the cell membrane. In this process mediated by the fusion glycoprotein, the fusion peptide plays an essential role in membrane binding and triggering fusion. Previously, we demonstrated that the parainfluenza fusion peptide (PIFP) oligomerizes int

New #RSCChemBio study pinpoints how two residues (F103 + Q120) power the parainfluenza fusion peptide’s membrane activity. One’s for fusion, the other’s for the teamwork.

#OpenAccess #advancearticle #Virology #Peptides #MembraneBiology

doi.org/10.1039/D5CB...

RaPID discovery of cell-permeable helical peptide inhibitors con-taining cyclic β-amino acids against SARS-CoV-2 main protease Structurally constrained cyclic β-amino acids are attractive building blocks for peptide drugs because they induce unique and stable conformations. Introduction of (1S,2S)-2-aminocyclopentanecarboxylic acid [(1S,2S)-2-ACPC] into peptides stabilizes helical conformations, so improving proteolytic stability and cell

Tougher peptides, smarter targets 🔒🧬

Cyclic β-amino acid–based helical peptide library leads to stable, cell-permeable SARS-CoV-2 Mpro inhibitors! New #RSCChemBio #advancearticle shows off RaPID selection power 💥

doi.org/10.1039/D5CB...

Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin Chuangxinmycin (CXM) is a promising antimicrobial compound targeting bacterial tryptophanyl-tRNA synthetase (TrpRS), an essential enzyme in protein synthesis. The detailed inhibitory mechanism of CXM, particularly in clinically relevant pathogenic bacteria, is poorly understood. In this study, based on the determin

Zoom in on CXM 🔬

New #RSCChemBio study reveals how chuangxinmycin hits bacterial TrpRS enzymes—but not human ones. 10 crystal structures + MD sims = a blueprint for selective antibiotic design.

#RSCchembio #StructuralBiology #Antibiotics #TrpRS #AMR
doi.org/10.1039/D5CB...

Turn-on fluorescent glucose transport bioprobe enables wash-free real-time monitoring of glucose uptake activity in live cells and small organisms The direct link between sugar uptake and metabolic diseases highlights the iminent need for molecular tools to detect and evaluate alterations in sugar uptake efficiency as approaches to identify disease-relevant metabolic alterations. However, the strict requirements of facilitative glucose transporters reg

✨ Sugar, lit. ✨

GluRho is a new glucose mimic that uses GLUTs 1–4 to light up sugar transport in live cells (and flies!). Great tool for tracking uptake with no metabolic interference.
New in #RSCChemBio #OpenAccess #advancearticle

doi.org/10.1039/D4CB...

Exploring sequence- and structure-based fitness landscapes to enhance thermal resistance and activity of endoglucanase II with minimal experimental effort Enhancing the performance of cellulases at high temperatures is crucial for efficient biomass hydrolysis—a fundamental process in biorefineries. Traditional protein engineering methods, while effective, are time-consuming and labour-intensive, limiting rapid advancements. To streamline the engineering process, we t

Hotter enzymes, faster: 🔥

This #RSCChemBio study shows EVmutation outperforms FoldX in predicting cellulase variants with up to 4.4× more activity & longer life at 75 °C!
#OpenAccess #advancearticle #ProteinEngineering #Enzymes #Biotech

DOI doi.org/10.1039/D5CB...

#RSCPoster 2025 winners! | Royal Society of Chemistry | 22 comments We are thrilled to announce the amazing winners of #RSCPoster 2025! 🎉 Congratulations to all the winners for their outstanding achievements in #RSCPoster and… | 22 comments on LinkedIn

Congratulations to the winners of #RSCChemBio of #RSCPoster over on LinkedIn, Nicolas Cornelissen and Atanu Ghosh. A huge thank you also to all participants for making this a lively event.

It was great to be a session chair alongside Lyn Jones and Ali Tavassoli.

www.linkedin.com/posts/roysoc...

Chemo-enzymatic production of base-modified ATP analogues for polyadenylation of RNA Base-modified adenosine-5′-triphosphate (ATP) analogues are highly sought after as building blocks for mRNAs and non-coding RNAs, for genetic code expansion or as inhibitors. Current synthetic strateg...

Interesting contribution to #RSCChemBio at #RSCPoster over on LinkedIn by Nicolas Cornelissen. An exciting method for the chemo-enzymatic synthesis of base-modified ATP analogs and their use for making highly modified, polyadenylated RNA. pubs.rsc.org/en/content/a...
www.linkedin.com/posts/nicola...

A Unified Phosphoramidite Platform for the Synthesis of Morpholino Oligonucleotides and Diverse Chimeric Backbones Phosphorodiamidate Morpholino Oligonucleotides (PMOs) have been well established in the milieu of FDA-approved oligonucleotide-based drugs in the past decade. Given their relevance in antisense therap...

Interesting contribution to #RSCChemBio at #RSCPoster over on LinkedIn by Atanu Ghosh. An exciting method for the automated synthesis of morpholino oligonucleotides with diverse backbones. pubs.acs.org/doi/full/10....

www.linkedin.com/posts/atanu-...

If you are participating with a poster in the #RSCChemBio subsection, please feel free to reach out to me, so that we can discuss your science.

If you are not actively partaking, make sure to check out all the amazing posters by following #RSCChemBio on LinkedIn. (2/2)

#chemsky #ChemBio

Very excited for the virtual #RSCPoster conference by @rsc.org over on LinkedIn that is happening on March 4th and 5th and to be a subject chair for #RSCChemBio together with Lyn Jones and Ali Tavassoli. (1/2)

www.rsc.org/our-events/r...

Do you want to present your research to a global audience?

Then you should check out, #RSCPoster, which will happen on March 4th to 5th. Very excited to chair the #ChemBio part #RSCChemBio together with Lyn Jones and Ali Tavassoli.

Click this link for all information: www.rsc.org/our-events/r...

Do you want to present your research to a broad global audience?

Then you should check out, #RSCPoster, which will happen on March 4th to 5th. Very excited to chair the #ChemBio part #RSCChemBio together with Lyn Jones and Ali Tavassoli.

Click this link for all information: www.rsc.org/our-even...