New this month in JHC: "Akkermansia muciniphila Selectively Reshapes Small Intestinal Cell Populations."

Click to read: journals.sagepub.com/doi/abs/10.1...

#epithelium #tuftcells #immunofluorescence

In a new Nature study, researchers from the @alleninstitute.org and their collaborators found that pain-sensing nerves in the gut, known as TRPV1⁺ neurons, help regulate #TuftCells.

🔬 Learn more about their work and see their incredible images: https://bit.ly/4rIafK2

This theory is supported by evidence indicating that LC involves #neuroinflammation & #tuftcells in the urogenital tract can activate neural & immune pathways.
The potential link to LC
-Persistent neuroinflammation

#Medsky🧪 #immunosky #Neurosky @cp-cellreports.bsky.social This study demonstrates a complex association between UTCs . ( #Tuftcells in the #urethra )& a several neurochemically distinct types of sensory nerve fibres. It establishes #neurogenicinflammation as a local defence mechanism triggered

Let's not forget that apart from science advocacy the Rauch lab also does kick-ass science!
Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!