#SmoothMuscleCell-derived #Semaphorin3A protect against🐭thoracic #AorticDissection #AorticAneurysm (BAPN)

Evidence from🐭SM22a-Cre overexpression or KO of Sema3a

SEMA3A ⬇️in🐭👤dissected aortas

Direct impacts on SMC or adventitial #VasaVasorum?

#Angiogenesis 2025
link.springer.com/article/10.1...

Pathobiology of Aortic Aneurysms & Dissections
Synthesis of Recent Investigations+Evolving Insights
#AortaEd

Outer media damage "occurring as a consequence of Hypertension &/or a facilitative genetic profile producing dysfunctional #VasaVasorum"

#JACCAdv 2025
www.sciencedirect.com/science/arti...

On #VasaVasorum remodeling in human #ThoracicAorticDisease

GLUT1+ hypoxic medial SMC are crying out for more oxygen!💀

Medial Hypoxia and Adventitial Vasa Vasorum Remodeling in Human Ascending Aortic Aneurysm

@mariebillaud.bsky.social #FrontCVM 2018
www.frontiersin.org/journals/car...

Wild-type Transthyretin Amyloid Deposition in an #AscendingAorticAneurysm

#TTRAmyloidosis

1 case
#VasaVasorum Arteriole only
Not detected in Aortic Media, nor Heart

#AortaEd

#JACCCaseReports 2024
www.sciencedirect.com/science/arti...

TIMP3 in Elastase-induced🐭Thoracic vs Abdominal #AorticAneurysm

TIMP3 KO
⏫Aorticφ, loss of contractile SMC, MMP2/9, inflammation, permeability
More #VasaVasorum in injured thoracic aorta only

TIMP4 KO
No impact

Zamaneh Kassiri lab #JMCC 2023
www.sciencedirect.com/science/arti...