🤵Artery Super-enhancer (H3K27ac ChIPseq) analysis (127 TFs)▶️
PRDM16 as a positive regulator of Injury-induced (not developmental) Proliferation of Vascular Smooth Muscle Cell😎

Any role in SMC-to-brown adipocyte conversion?😁

@jiliang-zhou.bsky.social #JMCC 2026
www.sciencedirect.com/science/arti...

FABP4, marker of worse prognosis in cardiovascular disease, induces neutrophil's proatherogenic phenotype which is modulated by semaglutide This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

🆕in JMCC: FABP4 emerges as a marker of worse CVD prognosis🫀 Elevated FABP4 drives proinflammatory, proatherogenic neutrophil phenotypes, while semaglutide lowers FABP4 & dampens leukocyte migration & platelet activation pathways 💊 #JMCC #Atherogenisis

www.jmcc-online.com/article/S002...

#TransferrinReceptor1 Antibody TSP-A18 i.p. in🐭+ANGII
⏬ #AorticDilation
⏬Medial thickness
⏬Adventitial fibrosis
⏬TfR1 Ferritin in #SmoothMuscleCell
↔️blood pressure

In vitro TfR1 Ab PPMX-T003
⏬intracellular iron (FerroOrange)
⏬ proliferation migration

#JMCC 2025
www.jmcc-online.com/article/S002...

TIMP3 in Elastase-induced🐭Thoracic vs Abdominal #AorticAneurysm

TIMP3 KO
⏫Aorticφ, loss of contractile SMC, MMP2/9, inflammation, permeability
More #VasaVasorum in injured thoracic aorta only

TIMP4 KO
No impact

Zamaneh Kassiri lab #JMCC 2023
www.sciencedirect.com/science/arti...