Adult #SmoothMuscleCell #TransferrinReceptor1 KO 🐭+ 1 ANGII or 2 DOCA salt
⏬ #AorticDilation
⏬Medial thickening
⏬Elastin breaks
⏬4HNE #LipidPeroxidation
⏬Ferritin Not divalent metal transporter 1
↔️blood pressure

#HypertensRes 2025
www.nature.com/articles/s41...

#TransferrinReceptor1 Antibody TSP-A18 i.p. in🐭+ANGII
⏬ #AorticDilation
⏬Medial thickness
⏬Adventitial fibrosis
⏬TfR1 Ferritin in #SmoothMuscleCell
↔️blood pressure

In vitro TfR1 Ab PPMX-T003
⏬intracellular iron (FerroOrange)
⏬ proliferation migration

#JMCC 2025
www.jmcc-online.com/article/S002...