Adult #SmoothMuscleCell #TransferrinReceptor1 KO 🐭+ 1 ANGII or 2 DOCA salt
⏬ #AorticDilation
⏬Medial thickening
⏬Elastin breaks
⏬4HNE #LipidPeroxidation
⏬Ferritin Not divalent metal transporter 1
↔️blood pressure

#HypertensRes 2025
www.nature.com/articles/s41...

#TransferrinReceptor1 Antibody TSP-A18 i.p. in🐭+ANGII
⏬ #AorticDilation
⏬Medial thickness
⏬Adventitial fibrosis
⏬TfR1 Ferritin in #SmoothMuscleCell
↔️blood pressure

In vitro TfR1 Ab PPMX-T003
⏬intracellular iron (FerroOrange)
⏬ proliferation migration

#JMCC 2025
www.jmcc-online.com/article/S002...

Early-onset #AorticDilation (Z>2) in young patients with #AutosomalDominantPolycysticKidneyDisease #ADPKD
n=97, 9.3 y/o

Prevalence
Annulus 5.2%
SoV 15.6%
STJ 17%
Ascending aorta 11.1%

Aortic diameter ➕corr. cyst burden
#Ciliopathy?🧐

#AortaEd
#KIReports 2024
www.sciencedirect.com/science/arti...

A must-read for anyone interested in BAPN-induced🐭#Aortopathy

Comprehensive info:
BAPN Dosage/Timing
🐭Strain/Age/Sex
Aortic Regionalization
#AorticDilation
#AorticDissection
#AorticRupture

#AortaEd

Hong Lu, Alan Daugherty labs @biorxiv-physio.bsky.social 2023
www.biorxiv.org/content/10.1...