HSPA8 promotes the progression of gastric cancer by activating the canonical Wnt pathway and glycolysis.
Ge, Peng et al.
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#GastricCancer #WntPathway #HSPA8

Inhibition of microRNA-126-3p attenuates ischemic stroke by targeting endogenous neuroprotective receptor LRP6 in the Wnt/β-catenin signaling pathway MicroRNA-126 (miR-126) has emerged as a potential key regulator in ischemic stroke. Yet, its exact mechanism of action is still unexplored. This study aims to investigate whether miR-126 targets and r...

Insight into stroke recovery!
miR-126 worsens brain injury by suppressing LRP6 in the Wnt/β-catenin pathway. Blocking it restores signaling, reduces cell death, and improves outcomes - a promising new stroke therapy target.
#StrokeResearch ##miR126 #WntPathway

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This review explores #Wntpathway activation, its #crosstalk with other signaling pathways, & its role in diseases. It also analyzes current strategies targeting the Wnt pathway and assesses Wnt-targeted therapies. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...