Another possibility for NK cells: model of HIF1a knockout mice can use IL-18 to turn a cold tumor hot. Human cancers with high NK/IL-18/INFgamma signals have better prognosis. Can we use a HIF1a inhibitor to drive this in people like in mice?? #AACR21 #AACRSSP
what I learned at #AACR21 as part of #AACRSSP (where you have to watch things you normally wouldn't): teaching NK cells to remember how to kill those damn cancer cells. Would love to know if this is a possibility in #breastcancer #bcsm
Look who I saw when I logged into #AACR21 this AM: fellow @metavivor board member Barb Bigelow! #AACRSSP
Dr Lo Russo mentions team members like biostatisticians and money people, but fogets to metntion the most important team members (and ones most investigators also neglets to include): patient #advocates. we can help you formulate the most impactful questions #aacrssp #aacr21
Watched @Nikhilwagle's #AACR21 presentation on resistance in ER+ MBC. Great info on mechanisms and potential trials/options, but I watched at 2x speed so the brilliant Dr Nik sounded like Dr Mick(ey Mouse)! #AACRSSP #bcsm #metastaticbreastcancer
Another interesting talk from yesterday #AACR21 was on alpha emitter thorium coupled to an Ab that binds to HER2. Most of the slides were "do not post" but there is a clinical trial. clinicaltrials.gov/ct2/show/NCT04147819
#AACRSSP #bcsm...
interesting presentation yesterday by David Dornan of @BoltBio about a trastuzumab ADC that boost immune response in HER2+ cancers - turning cold tumors hot. Phase I/II trial in progress clinicaltrials.gov/ct2/show/NCT04278144 #AACR21...
For @Martha__Carlson and others who wanted to see my #AACRSSP #AACR21 poster designed to let #researchers know about @metavivor #metastaticbreastcancer #bcsm
Researchers at #AACR21: check out my @metavivor poster ADV32 - we fund researcher that will benefit those of us already diagnosed with #metastaticbreastcancer. 2021 cycle is closed but keep us in mind for 2022! We funded $4.4 MILLION last yr in the midst of the pandemic #AACRSSP
Zooming into #AACRSSP as a participant in the excellent scientist<->survivor program. Thankfully live sessions at #AACR21 are recorded because besides the SSP session there are 3 other sessions I want to watch right now! #INeedAClone
