#AcralMelanoma #DermatologyUK #EarlyDetection #CheckYourSkin #SkinCareNetwork

Editorial titled 'Risk Factors for Acral Melanoma Among US Veterans' by Andrew F. Olshan, PhD, discusses Agent Orange exposure and its effects on veterans, referencing a JAMA Dermatology study by Hwang et al5 on skin cancer risk.

💬 Editorial: A case-control study in US Vietnam veterans indicates a modest increased risk for #AcralMelanoma associated with presumptive Agent Orange exposure, but actual case numbers are low due to the cancer’s rarity.

ja.ma/4r2Wq8E

Current Surgical Management for Acral Melanoma Review the available evidence on surgical management for acral melanoma, and explore future perspectives and challenges for optimizing treatment strategies for this distinct melanoma subtype.

Review the available evidence on surgical management for acral #melanoma, and explore future perspectives and challenges for optimizing treatment strategies for this distinct melanoma subtype.

👉 buff.ly/WPZS6Gl

#OncSky #AcralMelanoma

Impact of Mechanical and Architectural Signals in the Tumor Microenvironment on Melanoma This study focuses on recapitulating architectural and mechanical cues from the melanoma tumor microenvironment. Mechanically compressed melanoma cells are more proliferative and acquire higher DNA d...

A new 3D lab model reveals how physical forces shape #AcralMelanoma, finding compression can damage #DNA, collagen structures can fuel cancer’s spread, and blocking key pathways may offer new treatment options.
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Amazing new work from @patriciapossik.bsky.social's group!!! Check it out - An amazing repository and characterisation including PDXs, sequencing, cell lines - with new biological insights! #acralmelanoma

Reactivating HOXD13 in cutaneous #Melanoma has a dual pro-tumorigenic role

1⃣VEGFA/SEMA3➡️Angiogenic switch
2⃣CD73➡️⏫ extracellular Adenosine➡️⏬T-cell infiltration

#SpatialTranscriptomics #Visium➡️➖Corr b/w HOXD13 & cytotoxic T-cell score in #AcralMelanoma

bioRxiv 2024
www.biorxiv.org/content/10.1...

Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment Single-cell immune profiling of tumor-infiltrating T lymphocytes in acral melanoma revealed increased NKG2A expression in antitumor TILs.

Last but not least, Minowa and colleagues show that #acralmelanoma is immunologically distinct from it's cutaneous #melanoma cousin, suggesting that a different therapeutic approach is needed for these patients. www.science.org/doi/10.1126/...