Anti-Friedel–Crafts alkylation via electron donor–acceptor photoinitiation - Nature Synthesis A transition-metal-free synthetic strategy for C–H alkylation of electron-poor aromatics is reported, which selectively alkylates the most electrophilic position of electron-deficient aromatics to exh...

Opposing Friedel-Crafts #alkylation regioselectivity with #light and #EDA complexes💡now made possible 💪

Check out the work by David now out in
@natsynth.nature.com

nature.com/articles/s44...