Certain Antibiotics Increase Bacterial Release of Inflammatory Vesicles, Potentially Worsening Inflammation During Infection Antibiotics are essential for combating bacterial infections, but new research reveals that some types may unintentionally amplify the body's inflammatory response. Bacterial extracellular vesicles (BEVs) are tiny bubble-like particles released by bacteria, carrying proteins, toxins, and other molecules that interact with the host's immune system. While inflammation helps fight infection, excessive amounts can damage tissues and contribute to severe conditions like sepsis. In a study using E. coli, researchers tested various antibiotics and found that those targeting the bacterial cell wall—particularly beta-lactams—caused a significant increase in BEV production. In contrast, antibiotics that inhibit protein synthesis or DNA replication triggered far fewer vesicles. This difference appears linked to how bacteria manage stress from cell wall damage, shedding more vesicles as a survival mechanism. The vesicles can enter the bloodstream, interact with blood vessel cells, and heighten inflammation, potentially complicating treatment in serious infections. However, the research emphasizes that antibiotics remain lifesaving tools and should not be avoided. Instead, these findings highlight the need to consider how different antibiotics influence both bacterial killing and the host's inflammatory response. This work points to a broader understanding of bacterial behavior under antibiotic pressure. Bacteria are not passive; they actively respond to treatment in ways that affect the body. Future studies could help clinicians select antibiotics that minimize excessive inflammation, especially in critical cases. The study underscores the importance of balancing infection control with managing the body's immune reactions for better patient outcomes.

Certain Antibiotics Increase Bacterial Release of Inflammatory Vesicles, Potentially Worsening Inflammation During Infection

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#antibiotics #inflammation #bacteria

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Antibiotics can trigger bacteria to release bubbles of inflammation tinder, making it harder to treat infection Antibiotics are designed to kill harmful bacteria and help the body recover from infection. But some antibiotics may also push bacteria to release tiny particles that can make inflammation worse.

💊 #Antibiotics 💊
Antibiotics are designed to kill harmful bacteria and help the body recover from infection. But some antibiotics may also push bacteria to release tiny particles that can make inflammation worse.

Antibiotics are ineffective against: A. Bacteria B. Fungi C. Parasites D. Viruses #antibiotics #phar Antibiotics are ineffective against: A. Bacteria B. Fungi C. Parasites D. Viruses #antibiotics #phar

Antibiotics are ineffective against:
A. Bacteria
B. Fungi
C. Parasites
D. Viruses
#antibiotics #pharmacology #medications #therapy ... Continue to: www.facebook.com/113009240922...

Superbugs were already on the rise. The pandemic likely made things worse. A virus causes COVID-19, but many doctors still prescribe antibiotics to those who don't need them.

Superbugs were already on the rise. The pandemic likely made things worse.

www.nationalgeographic.com/science/arti...

#News #WorldNews #Science #Research #Health #PublicHealth #Medical #MedSky #COVID #COVID19 #Coronavirus #Pandemic #Virus #Superbugs #Antibiotics #AntibioticResistance

Association of nasopharyngeal Dolosigranulum pigrum and Corynebacterium species with post-acute sequelae of SARS-CoV-2 in a longitudinal cohort | Microbiology Spectrum This study highlights the importance of bacteria naturally found in the upper respiratory tract, particularly the nasopharynx (the nasopharyngeal microbiome), in shaping how severely COVID-19 affects ...

#microbiome #covid19 #sarscov2 #LongCovid #antibiotics

Ward et al. 2026 Microbiol Spectr 14:e02313-25

Association of nasopharyngeal Dolosigranulum pigrum and Corynebacterium species with post-acute sequelae of SARS-CoV-2 in a longitudinal cohort (Microbiology Spectrum)

doi.org/10.1128/spec...

🚨ICYMI: UBC TI #BestEvidence webinar recording

Oral vs IV Antibiotics
ti.ubc.ca/antibiotics-...

See also:

TI Therapeutics #antibiotics Letter
ti.ubc.ca/letter155

Patient handout: When are oral ABX the right choice? ti.ubc.ca/antibiotics-...

#MedEd #BetterPrescribing #ABX

Excretion of ampicillin from the body #ampicillin #pharmacology #pharmacy #antibiotics
... Continue to: youtube.com/shorts/tnYGG...

Elanco Animal Health’s profits have surged, showing how lucrative farm animal drugs remain despite rising concerns over antimicrobial resistance. 💊

veganfta.com/articles/2026/04/08/farm...

#publichealth #farming #antibiotics

🍄 this fungi is old… very old.
👁️‍🗨️ what did it show you ?

#Fungi diverged from other #Life around 1.5 billion years ago, with the glomaleans branching from the "higher fungi" at ~570 million years ago, according to DNA analysis. 🧐 #Penicillin Group of #Antibiotics derived from #Penicillium fungi

🚨ICYMI: How should we diagnose and treat skin + soft tissue infections?

Watch our UBC TI #BestEvidence webinar recording featuring Dr. Davie Wong

👉 bit.ly/3bh40b5

#MedEd #antibiotics #diagnosis #prescribing

Pharmalittle: We're reading about cheap generic obesity drugs in India, high demand for estrogen patches and more And more pharmaceutical news from the Pharmalot campus via the Pharmalittle newsletter

Pharmalot.. Pharmalittle.. Good Morning: We’re reading about cheap generic obesity drugs in India, high demand for estrogen patches and more news.. statnews.com/pharmalot/20... #pharma #weight #obesity #estrogen #340B #autism #FDA #antibiotics

The episode highlights key #AMR developments, including GARDP projects:
• zoliflodacin, a first-in-class oral antibiotic for uncomplicated urogenital gonorrhoea recently approved by the US FDA
• BWC0977, a novel broad-spectrum antibiotic candidate.

#AMR #Antibiotics #BBCPodcast

🎓 Warm congrats to Elvin Maharramov
@m-elvin.bsky.social on a successful PhD defense on the principles of designing #antibiotics with limited #resistance. A timely and elegant contribution to the field of #DrugDevelopment on how to design less resistance-prone antibiotics. More info below👇

What conditions can metronidazole be used for? #metronidazole #antibiotics #infection #pharmacy
... Continue to: youtube.com/shorts/eDM68...

Building smarter #antibiotics starts with understanding what holds #bacteria together. Meet Ellen Shepard, a #biochemistry student at #RIT who is researching how two proteins interact in hard-to-treat bacteria. 🧪

The #Gravity of Being Charged or #Neutral : Medium

Start-up is building the first #DataCentre to use #Human #Brain #Cells : New Sci

A single course of #Antibiotics can cause lingering changes in #Gut #Microbes : Nature

Latest #KnowledgeLinks

knowledgezone.co.in/resources/bo...

BBC World Service - Discovery, Superbugs: Resistance rising, part 1 Antibiotic resistant bacteria is rising - is a great global crisis on the horizon?

3 short podcasts on AMR worth listening to, including the economic challenges of new antibiotics:
www.bbc.co.uk/programmes/w...
www.bbc.co.uk/programmes/w...
www.bbc.com/audio/play/w...

#AntimicrobialResistance #AMR #PublicHealth #Antibiotics #BBC @peaseroland.bsky.social

Combined pollution of microplastics and antibiotics in agricultural ecosystems: occurrence, mechanisms, and risks Antibiotics and microplastics are two classes of emerging contaminants of significant concern in agricultural ecosystems. This review examines their i…

Combined #pollution of #microplastics and #antibiotics in #agricultural ecosystems: occurrence, mechanisms, and #risks

www.sciencedirect.com/science/arti...

Review: Lifeline, Southwark Playhouse - Everything Theatre This ambitious new musical celebrates Alexander Fleming’s discovery of penicillin, and warns of the deadly danger of antimicrobial resistance.

#Review: Lifeline @SwkPlay.bsky.social ★★★★

"It deals with complex material brilliantly, injecting love and vitality into material that could so easily be dry and academic."

#theatre #offwestend #antibiotics #musicals #antimicrobial #theatresky

everything-theatre.co.uk/2026/04/revi...

Which of the following is a commonly used sulfanilamide? A. Amoxicillin B. Sulfadiazine C. Erythromy Which of the following is a commonly used sulfanilamide? A. Amoxicillin B. Sulfadiazine C. Erythromy

Which of the following is a commonly used sulfanilamide?
A. Amoxicillin
B. Sulfadiazine
C. Erythromycin
D. Ciprofloxacin
#sulfanilamides #antibiotics #bacteria #infection ... Continue to: www.facebook.com/113009240922...

Antibiotics Review: Drug Classes, Prefixes & Mechanism of Action
#Antibiotics #Pharmacology #VikaasShandily #MedicalEducation #NursingStudents

We didn't discover #antibiotics because of better understanding of life or of bacteria. It was an accident without understanding. Today, we use antibiotics without understanding what we are doing to all life on Earth. We use antibiotics as weapons of mass destruction to eradicate all life on Earth.

What do we use #antibiotics for annually?

1. Pesticides (most for livestock feed)
4,000,000,000 kg

2. Livestock animals
110,000,000 kg

3. Human use
30,000,000 kg

We lose 2.5% of all insect biomass globally per year. "Now biologists are warning of a microbial extinction event"

#Extinction

What concentrations of ampicillin are observed in children? #ampicillin #antibiotics #pediatrics
... Continue to: youtube.com/shorts/ywN6t...

SimCells successfully target and kill drug-resistant bacteria We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and…

SimCells successfully target and kill #drug-resistant #bacteria ...

| #DrugResistance | #MicroSky | #antibiotics | #Superbugs | #AMR | Via @sciencex.bsky.social

phys.org/news/2026-03...

Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection - Nature Communications This case report presents a multi-omics case analysis of intravenous phage-antibiotic co-therapy in a patient with cystic fibrosis during an acute-on-chronic pulmonary exacerbation caused by multidrug-resistant Pseudomonas aeruginosa.

Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection

#Antibiotics & #PhageTherapy coordinate through ecological & immunologic complementarity rather than direct pharmacologic synergy

@scientiff.bsky.social

This documentary warns about the dangers of antibiotics like Levaquin and Cipro. The bad effects can happen weeks later, and patients have no idea what caused the disabilities, such as torn cartilage, etc.

This film is in 6 parts on YouTube. The FDA blackboxed these dangerous antibiotics. Doctors still prescribe them. Levaquin, Cipro, will disable you! Maybe not after the first dose, and maybe not immediately. Injuries are sustained weeks after taking the drug. #FDA #drugs #dangerousdrugs #antibiotics

Did Neanderthals Use Birch Bark Tar as an Antibiotic to Treat Wounds and Infections? Scientists created samples of the black resin using three methods and tested their effectiveness against two common bacteria

Did Neanderthals Use Birch Bark Tar as an Antibiotic to Treat Wounds and Infections?: Scientists created samples of the black resin using three methods and tested their effectiveness against two common bacteria @SmithsonianMag #Neanderthals #BirchBarkTar #Antibiotics #AncientMedicine #WoundCare

How graphene oxide kills bacteria while sparing human cells Hygiene in everyday items that touch the body—such as clothing, masks, and toothbrushes—is critically important. The underlying principle of how graphene selectively eliminates only bacteria has now…

How #graphene oxide kills #bacteria while sparing human cells ...

| #antibacterial | #microbiology | #antibiotics | #microbes | Via @sciencex.bsky.social