FDA Investigating Death Due to Neutralizing Antibodies to ADAMTS13... Since approval, the Food and Drug Administration (FDA) has received postmarketing reports of neutralizing antibodies to ADAMTS13, including one death, in congenital thrombotic thrombocytopenic purpura...

Hello #benignheme community. I am curious of the recent #FDA investigation about #Adzynma influences you to make any changes and what were those changes in your recommendation about the product www.fda.gov/vaccines-blo...

🩸 ISTH DIC score (overt ≥ 5)
Plt <50=2; 50–100=1
PT >6s=2; 3–6s=1
Fibrinogen <1.0g/L=1
D-dimer: >3× ULN=3; 1–3× ULN=2; none=0
#hemesky #medsky #coag #benignheme

🔬🩸Hemoglobin development (some fundamentals!)

Embryo
Hb Gower I = ζ2ε2
Hb Gower II = α2ε2
Hb Portland = ζ2γ2

Fetus
HbF = α2γ2

Adult
HbA = α2β2 ~97%
HbA2 = α2δ2 ~2–3%
HbF <1%
#hemesky #medsky #IMsky #benignheme #hemoglobin #pediatrics

Thank you #HTRS for providing this immersive experience discussing #vWD from theory to clinical practice at @lunduniversity.bsky.social engaging the evidence, guidelines, and world wide perspectives and now meeting new #BenignHeme colleagues from the US @rushadpatell.bsky.social & Canada!

A patient with no prior bleeding history, develops unexplained bleeding, high PTT, lowFVIII and a FVIII inhibitor.😳 Do you let them
Bleed, immunosuppress them- if so with what? Do you give them emicizumab? Dr Jacqueline Poston explains in “Advances in Acquired Hemophilia A”. #AHA #BenignHeme

>100k in the US, >4500 in SC have Sickle Cell Disease, the highest cause of 30-day readmission. Prioritizing #thalassemia and #scd care can make a difference. Dr Liz Traxler shares “Treatment and Emerging Therapies for SCD and Thalassemia” at today’s MUSC Multidisciplinary Heme Updates! #benignheme