Assessment of services for diagnosis, management and prevention of thalassaemia in India: The way forward Reader environment loaded

India has one of the world’s largest populations with #thalassemia major - a new article in #VoxSanguinis highlights key insights on diagnosis, management, and prevention.

Essential reading for healthcare professionals, policymakers, and anyone working in #thalassemiacare

🔗 doi.org/10.1111/vox....

Sir David J. Weatherall was born #OTD. He received a #LaskerAward in 2010 for discoveries concerning genetic blood disorders and for leadership in improving clinical care for thousands of children around the world with #thalassemia. ❤️‍🩹🧪 @oxforduni.bsky.social http://ow.ly/VXqO50Iehzi

DTI-ALPS Index Shows Promise as a Neuroimaging Biomarker in Beta-Thalassemia Major Researchers determined the DTI-ALPS index shows potential as a neuroimaging biomarker for assessing glymphatic dysfunction and cognitive impairment in β-thalassemia major.

Clinical Snapshot: Neuroimaging in Beta-#Thalassemia 📊

• Data: ALPS index significantly lower in patients vs controls (P < .001).
• Finding: Strong correlation between cognitive scores and ALPS index.

Read the review: https://bit.ly/4cafCwE

#HemeOnc #Hematology

Significant Barriers to Health Literacy Exist for Patients With Thalassemia Researchers determined there may be overestimation of disease understanding and barriers to health literacy among patients with thalassemia.

"Many patient populations with hereditary conditions such as #thalassemia have lived w the disease for their entire life, so it’s not surprising that they report high levels of confidence in health-related knowledge" @devasharma.bsky.social of @vumedicine.bsky.social.

https://bit.ly/4t4hyN6

#ASH25

Machine Learning Algorithm Effectively Distinguishes Alpha Thalassemia Subtypes Researchers determined a machine learning algorithm may be the optimal method for distinguishing beta thalassemia subtypes.

A #machineLearning algorithm may be the optimal method for distinguishing beta #thalassemia subtypes, with greater accuracy than would be expected relying on clinical features alone.

https://bit.ly/49JIkTe

Horror in MP where 6 kids got HIV after blood transfusions at a govt hospital. 350 donors under probe.

A system meant to heal caused irreversible harm. 💔

Who is accountable?

#Funtellect #MedicalNegligence #HealthcareCrisis #patientsafety #MadhyaPradesh #Thalassemia #HIV #India

Parents in India devastated as children with thalassemia test HIV positive — BBC News The five cases in Madhya Pradesh state come weeks after a similar incident was reported in Jharkhand state.

apple.news/AGt_8hltWSrG...
#thalassemia
#HIV
#MadhyaPradesh,India

❓Is it possible to cure pediatric #thalassemia even w/o a fully matched family donor? This study shows that transplants from matched unrelated donors can achieve success rates approaching 90%, expanding access to curative therapy.
🆓https://doi.org/10.46765/2675-374X.2025v6n1e292
#Hematology #JBMTCT

A girl who grew up on monthly transfusions. Today she is a mother. This is a story about one young woman who lived through monthly blood transfusions and still became a mother. It is also the story of thousands of children who are failed every month by a system that

One girl with #thalassemia became a mother. Thousands still fight for a single unit of #blood.

Check out my new blog: open.substack.com/pub/vikkypae...

Thank you to Ali Taher for speaking with us recently and providing valuable insight into the management of acute complications of #thalassemia that may present to the emergency department.

Watch the interview here:

👉 buff.ly/yL0drrc 👈

#Hematology #BloodSky #HemeSky #MedSky

What are the key risk factors for the development of bone disease in patients with #thalassemia? 🩸🦴

Julian Waung provided insight into this in a recent interview – watch here:

👉 buff.ly/Oe2kknT 👈

#Hematology #BloodSky #HemeSky #MedSky

What should the optimal pre-transfusion hemoglobin target be in patients with thalassemia? 🤔🩸

We caught up with Maria Domenica Cappellini recently to find out!

Click here to watch the interview:

🎥 👉 buff.ly/B8HDjTL

#Thalassemia #Hematology #BloodSky #HemeSky #MedSky

🚨 #BREAKING | In a grave incident at Chaibasa Jharkhand, five children with thalassemia have tested HIV-positive following suspected contaminated blood transfusions a probe into a local blood-bank is now underway.

#HIVPositive #Thalassemia #Jharkhand

🧪 New RCT from Tehran shows chicory extract significantly reduces serum ferritin in β-thalassemia patients. A promising step toward safer, plant-based iron management. #Thalassemia #Chicory #ClinicalTrial #IranHealth #MedicalResearch #TUMS #TPM

Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies Sickle cell disease and β-thalassemia, two major β-hemoglobinopathies, pose significant clinical challenges globally. Current treatments often face limitations in efficacy and tolerability. The transc...

Thrilled to share new work from Jun Liu & collaborators (with minor contributions from our lab), now on bioRxiv: SH6, a small molecule that boosts fetal hemoglobin, offering a new path for sickle cell + β-thalassemia therapies.
👉 www.biorxiv.org/content/10.1...
#SickleCellDisease #Thalassemia

FDA Extends Review of Mitapivat for Alpha- and Beta-Thalassemia The FDA has extended the review period for the sNDA for mitapivat for the treatment of adults with NTD and TD alpha- or beta-thalassemia.

The @fda.gov has extended the review period for the supplemental New Drug Application for mitapivat in the treatment of adults with NTD and TD alpha- or beta-#thalassemia. From @medicalprofref.bsky.social.

https://bit.ly/4m4hDMh

Researchers developed a low-cost method to screen newborns for thalassemia and hemoglobin disorders, aiding early treatment and improving health outcomes！

#Meded #SoMe4PedSurg #Pediatrics #Thalassemia #Hemoglobin

link.springer.com/article/10.1...

Prevalence of Depression in Patients with β-Thalassemia as Assessed by the Beck’s Depression Inventory β-Thalassemia (β-thal) is a frequent, chronic hereditary disease, and a plausible cause for psychological disorders. In this cross-sectional study, we aimed to identify the rate and severity of dep...

Young patients with #beta_thalassemia are prone to #depression. We showed a high #prevalence in #children with #thalassemia a few years ago and I wonder why this #data is not updated very well!
www.tandfonline.com/doi/full/10....

Yuet Wai Kan, #LaskerLaureate, pioneered the use of recombinant DNA technology for diagnosing genetic diseases, including prenatal testing for #sicklecell anemia and #thalassemia. laskerfoundation.org/winners/diag...
Read a feature: laskerfoundation.org/in-utero-gen... 🧪

RADeep

🔗 Follow us to stay updated on insights, progress, and impact from the RADeep community: bit.ly/4dOrbsf
#RareDiseases #RareAnemia #PatientRegistry #RADs #thalassemia #thal #SickleCellDisease #SCD

Seminar Announcement. Evangelia Vlachodimitropoulou, MBBS, PhD, Consultant in Maternal & Fetal Medicine, King’s College Hospital, will present: "In Utero Transfusions Beyond 35 Weeks Gestation in Alpha Thalassemia Major." This international seminar series is hosted by the UCSF Center for Maternal-Fetal Precision Medicine. It is a 'virtual' event and requires registration at: Register: tinyurl.com/ATM-Jun2025.

SEMINAR: Please join us on 6/12, 8am PDT, when Dr. Evangelia Vlachodimitropoulou from King’s College Hospital, will present “In Utero Transfusions (IUT) Beyond 35 Weeks Gestation in Alpha #Thalassemia Major” REGISTER: tinyurl.com/ATM-Jun2025

#HITAP participated in a stakeholder consultation in #Vientiane on #HTA & #Thalassemia research in #LaoPDR, led by #LOMWRU & #UHEP with #MORU support.
Chaired by Minister of Health, Lao PDR, & facilitated by the #UHS President, the initiative underscores academia’s role in shaping health priorities.

At #EBMT25, Mattia Algeri provided valuable insights into considerations for selecting patients with transfusion-dependent #thalassemia for allogeneic transplant or gene therapy.

Watch the exclusive interview here:
👉 buff.ly/CetMOvd

#BMTsm #Hematology #BloodSky #MedSky #HemeSky

It’s World Thalassemia Day,

Today aims to spread awareness of this condition, spreading love to people who suffering from this disease, and to hopefully move forward in finding better treatment. ❣

#thalassemia #thalassemiaday #thalassemiaawareness #mayholiday #artdaily #artchallenges #digitalart

Join our committee for a virtual public session, April 7, to learn about the challenges and opportunities to improve care for individuals with #Thalassemia, a group of inherited #BloodDisorders. Register here: buff.ly/HQDLcYj

>100k in the US, >4500 in SC have Sickle Cell Disease, the highest cause of 30-day readmission. Prioritizing #thalassemia and #scd care can make a difference. Dr Liz Traxler shares “Treatment and Emerging Therapies for SCD and Thalassemia” at today’s MUSC Multidisciplinary Heme Updates! #benignheme

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Preprint available at: lnkd.in/ekCNsNWa

🚑 I examine the challenges humanitarian projects face when planning an ethical exit, national staff experiences of power dynamics & continuity of patient care⚕️

#noncommunicabledisease #thalassemia #humanitarianaid #humanitarianhealthcare #lebanon

Transfusion efficacy of leucoreduced packed red blood cells prepared by two different methods: A randomized controlled trial in transfusion‐dependent thalassaemia patients (FUEL trial) You have to enable JavaScript in your browser's settings in order to use the eReader.

Read more 🔗 onlinelibrary.wiley.com/doi/epdf/10.... #Transfusion #BloodResearch #Thalassemia

Our February issue is live!🙌

Featuring #iGAS infections in Australia, Hong Kong #Genome Project, #Thalassemia Registry in Singapore, new #ML tool to guide cervical cancer screening & more!

🖋️Editorial: When #bushfires become the "new normal"

🎨Cover: Ms Desiree Tse from HKGI
🔗 tinyurl.com/ycydsrdz