A schematic illustration shows substrate-bound mTORC2 at the plasma membrane and mTORC1 at the surface of the lysosome

Explore the structural and mechanistic basis of the the PI3K/AKT/mTORpathway in this latest review from #biochemj #mTOR #AKT #PI3K #CancerBiology https://doi.org/10.1042/BCJ20253108

Onward into metabolism. Kicking off the pm session with Grace Gong (LMB) and John Burke (UVic) #iubmbKinases @iubmb.bsky.social We thank @biochemsoc.bsky.social #BiochemJ for their support of this session. The weather couldn’t even lure us away!

Structural Insights into allosteric inhibition of HRI kinase by heme binding via HDX-MS Heme-Regulated Inhibitor (HRI) is one of the four mammalian kinases that phosphorylate eIF2α, facilitating a cellular response to stress through the regulation of mRNA translation. Originally identifi...

Structural Insights into allosteric inhibition of HRI kinase by heme binding via HDX-MS #BiochemJ portlandpress.com/biochemj/art...

Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method. Inositol plays key roles in many cellular processes. Several studies focussed on the quantitative analysis of phosphorylated forms of inositol, enabled by analytical tools developed to detect these hi...

Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method. #BiochemJ portlandpress.com/biochemj/art...

#Hypertension #SmoothMuscleCell #Microtubule

Spontaneous Hypertensive rat Mesenteric Artery
#Acetylome
TUBA1A α-tubulin K40Ac⏫

Tubacin HDAC6i➡️
⏫endothelium-dependent vasorelaxation
⏬endothelium-independent relaxation (via⏫SMC MT stability?🧐)

#BiochemJ 2024
portlandpress.com/biochemj/art...

Ubiquitin E3 ligases in the plant Arg/N-degron pathway Regulation of protein longevity via the ubiquitin (Ub) — proteasome pathway is fundamental to eukaryotic biology. Ubiquitin E3 ligases (E3s) interact with substrate proteins and provide specificity to...

How many E3 ligases participate in the plant Arg/N-degron pathway? Our review of the key players in the pathway and perspectives on BIG (UBR4) and PRT7 (UBR7) is now out at #Biochemj. portlandpress.com/biochemj/art...