New preprint alert!
What keeps ANKZF1 out of mitochondria—until it's needed?
We show how its N-terminal segment masks an internal mitochondrial targeting signal.
Check it out on bioRxiv: biorxiv.org/content/10.110… #biorxiv_cellbio #mitochondria #proteintrafficking

In such cells, we noticed a quick clustering of nuclei, visible as soon as two or more cells started to fuse. The zone of nuclei clustering apparently hosted groups of growing lipid droplets (LD), accumulating over time, while mitochondria were moving away from this region and redistributed across the cytoplasm. Within the nuclei, nucleoli appeared denser and rounder upon infection (Figure 1C). We next determined which of these cellular events were due to the infection itself or the result of syncytia formation. To differentiate between these possibilities, we recorded cells that fused together in the absence of SARS-CoV-2, after transient expression of Syncytin-1, a fusogenic protein involved in the formation of placental syncytiotrophoblasts30.

Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling.

#biorxiv_cellbio #ML

www.biorxiv.org/content/10.1...

Elated to present our latest work which takes us one step closer to understanding how the motor protein cytoplasmic dynein 1 is regulated in living cells:

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#preprint #biorxiv_cellbio