Candidalysin balance lets Candida albicans silently colonize the mouth

Candida albicans strain 101, with low candidalysin production, persists in oral mucosa, whereas high‑toxin strain SC5314 induces rapid inflammation and is cleared in days. Read more: getnews.me/candidalysin-balance-let... #candida #candidalysin

Dose makes the difference! #Candidaalbicans uses the toxin #candidalysin not only to cause infections but also to quietly colonize the mouth – too little fails, too much triggers immune defense.

@natmicrobiol.nature.com
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picture credits: Erik Böhm, @leibniz-hki.de

How the common fungus Candida albicans colonizes the gut About 80% of people have the fungus Candida albicans in their gut. Although most of the time it persists unnoticed for years, causing no health problems, C. albicans can turn into a dangerous microbe…

How the common #fungus #Candida albicans colonizes the #gut ...

| #fungi | #infection | #antifungal | #candidalysin | #virulence | By @bcmhouston.bsky.social via @sciencex.bsky.social

Using #Candida mutant strains and fungal PAMPs, we showed that EGR1 activation is independent of major fungal virulence factors, including hyphal formation and #candidalysin release.

We also found that EGR1 upregulation relies on ERK1/2 and EGFR pathway activation.

🍄 #MycoSky

The Sugar Crush of the Fungal Toxin Candidalysin Sulfated glycosaminoglycans (GAGs) were found to be host cell targets of candidalysin, a cytolytic toxin secreted by the fungal pathogen Candida albicans. Exogenous GAGs protected host cells from dama...

This study highlights a shift in understanding how fungal toxins like #candidalysin interact with host cells. Instead of proteins, sugars play a critical role in this interaction…

communities.springernature.com/posts/the-su...

www.nature.com/articles/s41...