Development of a Standard Definition of “No-option” and “Poor-Option” for Revascularisation in #ChronicLimbThreateningIschemia #CLTI

Modified Delphi process for Consensus
8 closed+7 open Q for 157 vascular specialists, 30 countries (w/o 🍁🀄specialist...)

#BJSurg2026
academic.oup.com/bjs/advance-...

#Cuproptosis in #ChronicLimbThreateningIschemia

Bulk RNAseq re-analysis ➡️
12 Cuproptotic genes⏬in👤CLTI Gastroc muscle

Copper chelator Ammonium Tetrathiomolybdate▶️
⏬Muscle protein lipoylation
⏫Limb reperfusion
in diabetic🐭 #LimbIschemia

#FreeRadicBiolMed 2025
www.sciencedirect.com/science/arti...

Aplagon secures EUR 7 million for APAC phase 2a trials - PharmaTimes Funding led by new investors FSG and EIC Fund

#Aplagon #APACtherapeutic #thromboinflammatorydiseases #heparinproteoglycanmimetic #antiplatelet #anticoagulant #mastcellderivedheparinproteoglycans #antithrombotic #antiinflammatory #peripheralarterialocclusivedisease #chroniclimbthreateningischemia #PAOD #CLTI
pharmatimes.com/news/aplagon...

#ChronicLimbThreateningIschemia #LimbIschemia

Competing risk analysis to estimate #Amputation incidence & risk in #LowerExtremityPeripheralArteryDisease

7273 case + 5095 ctrl
2 yr f/up

journals.sagepub.com/doi/10.1177/...

A conundrum of arterialized capillaries & vascular dilation in #ChronicLimbThreateningIschemia

A very thoughtful framework to tackle microvascular insufficiency #PeripheralArteryDisease

Thanks for citing our 2 papers🙏

Brian Annex lab #EHJ 2023
academic.oup.com/eurheartj/ad...