Research insights: the latest updates from clinical papers We review the latest clinical research from high-impact medical journals and draw out the findings most relevant to your practice.

In our new monthly round-up, we review the latest clinical research from high-impact medical journals and draw out the findings most relevant to primary and community care nurses. Cahal McQuillan reports.

#ClinicalReport #NHS #GPNs #ClinicalResearch

Mice grow bigger brains when given this stretch of human DNA Finding adds to the bigger picture of how humans developed such large brains.

#Medsky🧪 #neurosky Taking a snippet of #geneticcode that is unique to humans & inserting it into 🐁 helps the animals to grow bigger brains than usual, according to a #Clinicalreport @nature.com

www.nature.com/articles/d41...

www.nature.com/articles/s41...

www.nature.com/immersive/d4...

Adult phenotypes of genetic developmental and epileptic encephalopathies Vakrinou et al. conducted a cross-sectional study on adults with genetic developmental and epileptic encephalopathies, revealing diverse clinical, EEG, and

#Medsky🧪 #Neurosky This #clinicalreport that genetic developmental & #epilepticencephalopathies persist into adulthood with diverse phenotypes. 54.8% of cases had feasible
aetiology-based
treatments, highlighting a need for genome-wide genetic testing in adults.

buff.ly/ZRL8abL

#Medsky🧪 #oncosky #pharmasky In this #clinicalreport mTORC1 regulates pyrimidine salvage by controlling the stability of its rate-limiting enzyme, UCK2. During nutrient depletion or #mTORC1inhibitor treatment . One critical aspect of cell proliferation

Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study - Journal of General Internal Medicine Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may occur after infection. How often people develop ME/CFS after SARS-CoV-2 infection is unknown. Objective To determine the inci...

Incidence and Prevalence of #NeuroCovid - ME /CFS : A #ClinicalReport
link.springer.com/article/10.1...
PDF Full

link.springer.com/content/pdf/...

#MedSky🧪#IDSky This #clinicalreport case represents a unique example of combined genetic and acquired risk factors for severe #COVID19 & #WestNilevirus infection. The patient harbours the heterozygous (p.Pro554Ser) missense variant in TLR3 gene and is homozygous for the CCR5432 deletion,

MedSky🧪 #Clinicalreport #Metabolomic Novel evidence suggesting that long-term increases in circulating #caffeine may reduce bodyweight and the risk of #osteoarthrosis and #osteoarthritis.

Combined protection of vaccination and nirmatrelvir-ritonavir against hospitalization in adults with COVID-19 Abstract. Among U.S. adults at risk for severe COVID-19 in Epic Cosmos, the lowest rate of hospitalization was among those receiving three or more mRNA vaccine

#PublicHealth #Viralimmunology #ClinicalReport Among 🇺🇸 adults at risk for severe #COVID19 the lowest rate of hospitalization was among those receiving 3 or more mRNA vaccine doses & #Paxlovid …

academic.oup.com/cid/advance-...

academic.oup.com/cid/advance-...

pubmed.ncbi.nlm.nih.gov/37806837/

Efficacy and Safety of 5-Day Oral Ensitrelvir for Mild to Moderate COVID-19 This randomized clinical trial assesses whether ensitrelvir reduces time to resolution of 5 common COVID-19 symptoms among patients with mild to moderate diseas

MedSky🧪#IDSky #Clinicalreport @JAMA_current Treatment with #ensitrelvir, an oral SARS-CoV-2 3C-like protease inhibitor developed in 🇯🇵 , shortened #COVID19 symptoms in people who received these #Antiviral within 3 days of symptom onset, researchers reported.

jamanetwork.com/journals/jam...