Structural & functional analysis revealed that the extracellular #chaperone #clusterin functions through two tails in preventing protein aggregation.

❕Paper: www.nature.com/articles/s41...
❕Press Release: www.biochem.mpg.de/structure-of...

#Alzheimers @natsmb.nature.com @pyustecheca.bsky.social

Urinary #Clusterin is a #Biomarker of Renal Epithelial #Senescence and Predicts Human Kidney Disease #Progression

#VisualAbstract by @Cteodosiu

www.kireports.org/ar...

@davidbaird86.bsky.social

Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication - Molecular Neurodegeneration Background Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a plethora of risk loci. However, the disease variants/genes and the underlying mechanisms have not been e...

#AlzheimersDisease protective allele of #Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron- #glia communication

Xiaojie Zhao, Yan Li, Siwei Zhang...Jubao Duan

bit.ly/433N1D9

Excited to share our new @elife.bsky.social in collaboration with @Schiller lab.: Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis doi.org/10.7554/eLif...

#ECMatrix #chaperone #Clusterin #ECMresearch #Collagen #Integrin #AFM #Proteomics