Antiseizure potential of the triple T‐type calcium channel blocker ACT‐709478 (apinocaltamide) in rodent models Objective T-type Ca2+ channels in the brain contribute to the generation of spike-and-wave discharges (SWDs). Absence seizures are defined by the occurrence of SWDs and are associated with impairmen...

Key point: ACT-709478 is a potent blocker of all three T-type Ca2+ channels without off-target activities.
onlinelibrary.wiley.com/doi/10.1111/...

#epilepsy #Ilae #epilepsia #absenceseizures #antiseizuremedication #convulsiveseizures #GAERS #TtypeCa2+channelblocker #WAG/Rij