This afternoon is all about rational design and mechanistic understanding #eucomc2025 Looking deeper into the intricacies of #ironcatalysed #crosscouplings with @theneidiglab.bsky.social @oxfordchemistry.bsky.social #NoMoreIronInBrackets

Pushing the boundaries of #organosodium reagents, we are incredibly excited to report their applications in #iron #catalysed #crosscouplings with Sobi Asako and Laurean Ilies at RIKEN 🇯🇵 @naturesynthesis.bsky.social
@unibe.ch #openaccess #TeamWorkMakestheDreamWork

www.nature.com/articles/s44...

Harnessing Organopotassium Reagents for Cross-Coupling with YPhos-Pd Catalysts: Opportunities, Applications, and Challenges With advances in the applications of earth-abundant organopotassium reagents in C–C bond forming processes, this study pioneers Pd-catalyzed cross coupling reactions between aryl halides and a range of aryl and benzylpotassium species generated by direct C–H metalation. Key for the success of this approach is the use of electron-rich ylide-substituted phosphine (YPhos) ligands, which enable fast conversion of the potassium species in solution. This protocol can be carried out in a one-pot manner at room temperature, without the need for purification of the in situ prepared organopotassium compounds or any additional additives, enabling the isolation of a broad scope of coupling products even on a gram-scale.

So excited to share our latest publication @pubs.acs.org in collaboration with Viktoria Gessner and her team using wonderful #YPhos in #PdCatalysed #crosscouplings of highly reactive #organopotassiums @ruhr-uni-bochum.de @unibern.bsky.social
#TeamWorkMakesTheDreamWork
pubs.acs.org/doi/10.1021/...