This study identifies SPP1+ #macrophages as regulators of #DiscDegeneration, expanding in diseased discs, driving matrix loss via #SPP1, while #exosome-directed #SPP1 blockade restores autophagy and offers a promising therapeutic path.

#OpenAccess: doi.org/10.1016/j.ge...

Researchers highlight how #PostTranscriptional regulation shapes #IntervertebralDisc homeostasis, identify aberrant RNA regulation as a driver of #discdegeneration, and present mechanistic insights to guide therapeutic repair.

#OpenAccess: doi.org/10.1016/j.ge...

So..... I have been re-referred to a Spinal Specialist.

I just can't right now.

So damn frustrated.

#Spine #Spinal #DiscDegeneration #SpinalStenosis
#Sciatica #Scoliosis #NerveDamage #ChronicPain #NESVOID

I'm extremely likely to have to go to the emergency room tomorrow which is going to put even more stress on our non existent funds, please help! #MutualAid #MutualAidRequest #HelpSky #Disabled #ChronicIllness #DiscDegeneration #CaudaEquina 💕💸