💡Online now - the Spotlight "Ancient enzyme diversification underpins octocoral chemical diversity" from @kdarragh.bsky.social.

#TerpeneSynthase #Diterpenes #BiosyntheticPathway #Octocorals #Evolution

Read it here 👉 authors.elsevier.com/a/1mURq3S6Gf...

Certain Kinds of Coffee Could Be Sabotaging Your Cholesterol Paper coffee filters can remove compounds in coffee that raise ‘bad’ LDL cholesterol, but certain brewing methods don’t use these filters.

I have a little one cupper moka pot and I'm thinking about buying a 4 copper for company. Read that paper filters the chemical that makes cholesterol. Have you ever tried a paper filter in your Moka pot? www.everydayhealth.com/heart-health... #diterpenes

Figure 1 from the paper by Bharadwaj Revuru, Gayathri Thashanamoorthi, Prathiba Demiwal, Debabrata Sircar, Sathishkumar Ramalingam, SmERF6 promotes the expression of terpenoid pathway in Salvia officinalis and improves the production of high-value abietane diterpenes, carnosol and carnosic acid, Plant and Cell Physiology, Volume 66, Issue 3, March 2025, Pages 411–425, https://doi.org/10.1093/pcp/pcaf007. The schematic diagram shows the representative biosynthetic pathway of CO in S. officinalis. Initially, GGPP is converted to miltiradiene through enzymatic steps mediated by CPS and KSL. Later, CYP76AH22/24 converts miltiradiene to ferruginol followed by further conversion to 11-hydroxy-ferruginol. Finally, CYP76AK6/8 mediated catalysis converts 11-hydroxy-ferruginol to CA. CA is immediately converted to CO.

Sage advice... 💡

Revuru et al. have succeeded in improving the content of pharmaceutically important #diterpenes in garden sage by overexpressing pathway-specific transcription factors leading to increased carnosol (4-fold) & carnosic acid (3-fold)

🔗 doi.org/10.1093/pcp/...

#plantscience

Exploring and expanding the natural chemical space of bacterial diterpenes - Nature Communications Unlike that in plants, fungi, and marine animals, bacteria are vastly underrepresented in the production of terpenoids. Here, the authors report a systematic screening of terpene synthases from…

Exploring and expanding the natural chemical space of #bacterial #diterpenes ...

| #bacteria | #Terpenoids | #hydrocarbon | #myxobacteria | #cyanobacteria | Via @natcomms.nature.com