A gut–brain axis on-a-chip platform for drug testing challenged with donepezil Current drug development pipelines are time-consuming and prone to a significant percentage of failure, partially due to the limited availability of advanced human preclinical models able to better re...

Fanizza et al. developed PEGASO, a gut-brain axis-on-a-chip platform for drug screening & personalized medicine. The team modeled the physiological passage of AD drug #donepezil in the new system. Check out the paper in @labonachip.rsc.org

pubs.rsc.org/en/content/a...

Donepezil for Fatigue and Psychological Symptoms in Post–COVID-19 Condition This randomized clinical trial investigates whether donepezil may be effective against post–COVID-19 fatigue and psychological symptoms among patients within 1 year of COVID-19 diagnosis.

These findings suggest that #donepezil should not be used for fatigue and psychological symptoms in #longcovid sequelas in a general population.

jamanetwork.com/journals/jam... @jama.com

Question: Which patient(s) experienced side effects while taking #Donepezil? Answer: http://bit.ly/d9dwm4 #sparql #hcls #pharma #linkeddata