Integrative In Silico and In Vitro Screening of Low Molecular Weight Compounds Targeting SARS‐CoV‐2 RNA Elements A combined virtual and nuclear magnetic resonance (NMR)-based screening approach identifies small molecules that bind conserved SARS-CoV-2 RNA structures. Diverse compound libraries are screened usin...

New publication alert 🎉
Our latest paper explores how small molecules can bind SARS-CoV-2 RNA, combining in silico screening with NMR experiments to uncover promising RNA-targeting candidates.

full text: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

#RNA #NMR #screening #drugtargeting

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain Structure-guided design of a sulfamoyl-modified analog of GS-441524 yielded a selective, high-affinity inhibitor of the SARS-CoV-2 macrodomain Nsp3b. The compound occupies the phosphate-binding pocke...

Have a look into our newest publication showing how GS-441524 derivatives can potently inhibit the SARS-CoV-2 macrodomain (Nsp3b), offering a structural roadmap for next-generation antiviral design.

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

#SARSCoV2 #NMR #drugtargeting #synthesis

What’s holding back precision medicine outside oncology? Precision medicine is finding success in cancer care, but not much elsewhere. The reasons why are often more economic than scientific.

#precisionmedicine #futureofhealthcare #drugtargeting #patientoutcomes #personalisedmedicine #biotech #precisiontherapeutics #biology #complexdiseases #MASH #genetictesting #geneticsequencing #healthtech #rarediseases #precisionmedicinedevelopment #precisionmedicineresearch zurl.co/DJ1K7

Optimization of Structure‐guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS‐CoV‐2 Targeting the RNA genome of SARS-CoV-2 is a viable option for antiviral drug development. We explored three ligand binding sites of the core pseudoknot RNA of the SARS-CoV-2 frameshift element. We it....

Congratulations to Betül and co-workers for this great work 🥳

"Optimization of Structure-guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS-CoV-2"

Full text: doi.org/10.1002/anie...

#nmr #SARS-CoV2 #rna #drugtargeting

Your DNA can affect a person’s response to medications. Genetic variants in genes can determine the level of drug uptake and/or drug metabolism, which results in patients requiring more or less of a medication.

#genetics #drugtargeting #genomics #geneticseducation #genes #DNA #RNA #laboratory