A recent interim analysis suggests that a lower, pharmacokinetic-guided dosing of #emicizumab for #hemophiliaA, rather than a body weight dosing, may perform as effectively, with no statistical difference in ABRs observed between both dosing methods: https://ow.ly/pEnm50YhjUm
#HemeSky #hemophilia
Early initiation of #Emicizumab treatment seems safe and effective for the management of acquired #HemophiliaA. Study in Seminars in Thrombosis and Hemostasis.
Read more: https://bit.ly/3ZvQvNf
#RareDisease #Hemophilia #Hematology
#Emicizumab delivers substantial clinical and economic benefits over recombinant activated factor VII (#rFVIIa) in Iraqi patients with #hemophilia A and inhibitors.
Read the full article in #JPHSR:
🔗 doi.org/10.1093/jphs...
The second question of the day!
See the answer and explanation on the next slide.
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @ash.edu.hematology.org
Today's first question!
See the answer and explanation on the next slide.
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
Facts about Hemophilia A: Rebalancing and RNA-Based Therapies
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
The second question of the day focuses on understanding complications in patients receiving fitusiran prophylaxis.
See the answer and explanation on the next slide!
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials
Today’s first question focuses on why a child on regular recombinant Factor VIII prophylaxis may still experience several bleeding episodes each year.
See the answer and explanation on the next slide!
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab
Facts about Hemophilia A: Non-Factor (Substitution) Therapies
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
Today’s question focuses on the type of viral vector most commonly used in gene therapy trials for Hemophilia A.
See the answer and explanation on the next slide!
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials
Facts about Hemophilia A: Treatment — Factor Replacement Era
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @thjournal.bsky.social @htrstoday.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
Today’s question focuses on safe management of breakthrough bleeding in a patient receiving emicizumab prophylaxis.
See the answer and explanation on the next slide!
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials
Facts about Hemophilia A:
Additional information on diagnosis and screening
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @sfthemostase.bsky.social @thjournal.bsky.social
Facts about Hemophilia A: Diagnosis and Screening
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @thjournal.bsky.social @htrstoday.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
Facts about Hemophilia A: Clinical Manifestations
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social @athnnews.bsky.social
Today’s question highlights the cytokine responsible for joint damage in Hemophilia A.
See the answer and explanation on the next slide!
#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders
New in The Journal of Haemophilia Practice: a real-world study in the UAE shows improved clinical outcomes with #emicizumab #prophylaxis in children and adults with severe #haemophilia A. https://doi.org/10.2478/jhp-2025-0013
#HemeSky #MedSky #BloodSky
New in The Journal of Haemophilia Practice: results from a #qualitative study exploring the experiences of people with severe #haemophilia A in the #HemiNorth cohort switching from factor VIII prophylaxis to #emicizumab. Open access, here: https://loom.ly/MvtKKe4
#HemeSky #MedSky #BloodSky
This #commentary from Cedric HERMANS MD PhD FRCP discusses the use of activated prothrombinase complex concentrate in patients on #emicizumab.
www.rpthjournal.org/article/S247...
The original article being discussed is here:
www.rpthjournal.org/article/S247...
In @eahad.bsky.social's latest podcast,
@majfbirkedal.bsky.social discusses using a subcutaneous drug delivery device to reduce treatment-related #pain in children with #haemophiliaA on #emicizumab. Read her paper in The Journal of Haemophilia Practice sciendo.com/article/10.2...
#HemeSky #MedSky
New in The Journal of Haemophilia Practice: a case series report from the Netherlands on the complexity of managing acquired haemophilia A, highlighting the role of #emicizumab: https://doi.org/10.2478/jhp-2025-0008
#AcquiredHaemophilia #CaseSeries #HemeSky #MedSky #BloodSky
💊 Implementing an Assay to detect Anti-drug Antibody against #Emicizumab: Experience from One Center in France 🇫🇷 ⬇️
📌 Auditeau et al. evaluated the effectiveness of a modified bridging ELISA in detecting anti-drug antibodies
Read more: 👉 www.thieme-connect.de/products/ejo...
#hemophilia #HemeSky
TH MAY 2️⃣0️⃣2️⃣5️⃣ISSUE ONLINE
✅#VenousThromboembolism in #Glioblastoma
💉the AGEHA Study: #Emicizumab for Acquired #Hemophilia A
🐹Cardiac Repair after #MyocardialInfarction is Controlled by Complement C5a Receptor 1
Read the complete issue at tinyurl.com/2cjjfxhn
The Journal of Haemophilia Practice recently published a paper reporting on #emicizumab prophylaxis for haemophilia A in Tanzania, highlighting considerations around access to #haemophilia treatment across Africa and in LMICs.
Open access here: doi.org/10.2478/jhp-...
#HemeSky #MedSky #BloodSky
In search of a #FVIII equivalence for non-factor therapies, we applied in vivo bleeding models 🩸 🐁 . This study suggests that a single FVIII equivalence is unlikely for #emicizumab #SIAmarstacimab and similar molecules.
Join our webinar on “Optimising Prophylaxis in Haemophilia A” by Prof. Cedric Hermans, Belgium followed by Practice session with Dr. SP Verma, Prof. Cedric Hermans, Dr. Sudhir Kumar Atri & Dr. Anupam Dutta on 11-04-2025.
Register: miceideas.com/webinar/regi...
#hemophilia #prophylaxis #emicizumab
Check out this fascinating review on the effects of emicizumab on surgical outcomes in Hemophilia A patients! 🏥
👍 www.rpthjournal.org/article/S247...
#hemophilia #emicizumab #bleeding
Join us for an insightful talk on 'Lab Monitoring and Management of Breakthrough Bleed on Emicizumab' by Prof. Dr. Johannes Oldenburg followed by a 'Practice Discussion'.
To register: miceideas.com/webinar/regi...
#haemophilia #emicizumab #bleedingdisorders
If you care for a child on emicizumab treatment please consider if your practice could benefit from our experiences.
It has made a world of difference to our patients. Read it here: doi.org/10.2478/jhp-...
#HemeSky #MedSky #hematology #hemophilia #emicizumab @majfbirkedal.bsky.social
New in The Journal of Haemophilia Practice: a paper on the use of a subcutaneous drug delivery device to reduce pain and distress in children with haemophilia A receiving emicizumab. Read it here: doi.org/10.2478/jhp-...
#HemeSky #MedSky #hematology #hemophilia #emicizumab @majfbirkedal.bsky.social
