Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair

BiRDS, a tetrahedral DNA-based Tri-miR-22 mimic system, penetrates #retina via #extraocular delivery, suppresses pathological #neovascularization, preserves neuronal integrity & blocks Wnt/β-catenin, offering a next-gen RNA #nanotherapy.
#OpenAccess #STTT: doi.org/10.1038/s413...