#FragLites offer a fast, chemically rich method to identify allosteric sites, guide probe development, and validate AI-generated structural models. Their ability to mimic key interaction residues makes them ideal for designing separation-of-function mutations and selective inhibitors. 🧵3/3

Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio
📖 www.sciencedirect.com/science/arti...

Looking forward to speaking at this on Tuesday. Apparently they are keen to hear about #fraglites and #dels - we will see www.nepic.co.uk/event/nepic-...