A single non-coding SNP in FPGS modulates folate drug efficacy in acute lymphoblastic leukemia: data-driven exploration and experimental validation - Molecular Biomedicine For over 70 years, methotrexate (MTX) has remained a first-line chemotherapeutic agent for acute lymphoblastic leukemia (ALL), playing a pivotal role in maintenance therapy. Understanding the genetic ...

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A single non-coding SNP in FPGS modulates folate drug efficacy in acute lymphoblastic leukemia: data-driven exploration and experimental validation doi.org/10.1186/s435...

#Folylpoly #glutamate #synthetase #NoncodingSNP #GeneticVariant #AcuteLymphoblasticLeukemia

#paulkornerseminar speaker Dr Emma Rath: 'What is the gene mutation causing a patient's #heartdisease? One of our detectives is a computer pipeline, gathering and presenting all the known information.' #geneticvariant #genomics #bioinformatics #science #sciencetwitter

#paulkornerseminar speaker Dr Emma Rath: 'The #geneticvariant that causes a patient’s #heartdisease is one in six million, our computer variant pipeline combs through them all.' #genomics #bioinformatics #womeninscience #science #sciencetwitter