🧠 This study suggests that targeting the CCL2/CCR2/ERK1/2 pathway may help overcome chemoresistance in #glioblastomas caused by cancer-associated fibroblasts!

👉 https://go.nature.com/3XI0cHu

Nanopore whole-genome sequencing of human sarcomas - EGA European Genome-Phenome Archive We performed single and multi-region nanopore whole-genome sequencing on human sarcoma samples from adult and paediatric patients.

So, first, we generated matched illumina (~120x) and @nanoporetech.com (~50x) for 99 tumours with complex rearrangement profiles: 57 diverse soft tissue #sarcomas, 28 #osteosarcomas and 14 #glioblastomas. All long-read data are accessible via the EGA:
ega-archive.org/studies/EGAS...

SCI member @michellemonje.bsky.social & others found GABAergic neuron-to-glioma synapses promote #DMG growth by depolarizing cells, enhancing proliferation. Lorazepam worsens DMG growth but has min effect on #glioblastomas, revealing subtype-specific neurophysiology. www.nature.com/articles/s41...

Glioblastoma: Surprising find of immune cells Glioblastomas are highly aggressive, usually incurable brain tumours. If all therapeutic options are exhausted, patients have an average life expectancy of less than two years.

Researchers at the 🇩🇪 @dkfz.bsky.social have made a surprising discovery regarding #glioblastomas: in the vicinity of these agressive 🧠 brain tumours, they found islands of highly potent immune cells. This may open up prospects for new therapies.