What do #ozempic and #harvoni have in common?
The only 2 medications patients have consistently asked me for by name in over 2 decades of being a liver doctor. #LiverTwitter #NAFLD #hcv
#Gilead announces it has licensed #epclusa and #harvoni generics in the US to #Asegua for 24k/12 wk course. This is a welcome first and steep list price discount for #HCV meds
AASLD/IDSA: 8 wk #harvoni now only recommended for treatment-naïve, non black,HIV neg, non cirrhotics w/ #HCV RNA <6 mil IU/ml
#Harvoni is effective and well tolerated in post-kidney transplant patients with hepatitis C virus @vinaynairdo onlinelibrary.wiley.com/doi/10.1111/ctr.12941/fu...
New #HCV black box warning for #HBV reactivation affects #harvoni #epclusa #viekira #zepatier #daklinza #sovaldi #olysio #technivie
#harvoni label expanded to GT 1,4,5,6 patients with decompensated cirrhosis including those post liver transplant https://t.co/0lc2Xyhjya
Harvoni induced Aki : first case report of ain #harvoni @ASNKidney @AJKDblog www.nature.com/ajg/journal/v111/n1/full...
Dr. O'brien: TT genotype and male gender may be better predictors #HCV relapse with #harvoni though the number is small #hepdart
Dr. O'brien: no statistically justifiable reason to use 6 million IU/ml to decide on 8 vs. 12 weeks of #HCV therapy with #harvoni #hepdart
Dr. Feld: in 2 patients who were not cured Y93H was detected at failure. Still role for #harvoni as 8 week data better #LiverLeader #liver15
Dr. Terrault: PPI used associated with #harvoni virological failure. Reason unclear. Also 8 week option underutilized #Liver15 #LiverLeader
Dr. Terrault: real world HCV-TARGET data show SVR12 rates with 12 & 24 wks of #harvoni compared to clinical trials #Liver15 #LiverLeader
Pr. Zeuzem: Y93H & IL-28b CC genotype correlated. Y93H non CC experienced cirrhotics get lower SVR12 w #harvoni #Liver15 #LiverLeader
No expected drug-drug interactions between #tenofovir alafenamide and #harvoni. https://shar.es/1u6sOg
@regulusRx initiated #HCV phase 2 studies for RG-101 in combination with #harvoni #daklinza and #olysio with interim data by end of year
Though shorter #HCV treatment duration is desirable, side effects & cure rate of #harvoni #viekira and #olysio are not the issue. ACCESS is!
#FDA "rescinding" of $MRK #HCV investigational drug breakthrough status is first ever, cited availability of other drugs #harvoni #viekira
The $ABBV v $GILD "exclusive" wars rage on
Aetna and Gilead Reach Deal on Hepatitis C Drug http://nyti.ms/1GbM8Kv #HCV #viekira #harvoni
OH Medicaid prior auth for #HCV rx w #viekira & #harvoni req signed pt contract pledging adherence to meds & abstinence from alcohol & drugs
I guess competition is a good thing. #HCV Drug Prices Fall So Low, No Exclusives Needed http://bloom.bg/1AJ4ywo via #harvoni #viekira
Updated #AASLD/#IDSA guidance has #Viekira Pak, #harvoni and #olysio/harvoni regimens as first line meds for #HCV GT1 http://www.hcvguidelines.org
AbbVie Prices Hepatitis C Drug 12% Below Gilead Rival http://buswk.co/1wUEfSn via #hcv #viekira #harvoni
#harvoni+RBV in decompensated HCV GT1 cirrhotics appears safe and effective. May also improve liver function and drop MELD score. #Liver14
Dr. Kottilil " 12 wks of #harvoni yields (49/50) 98% SVR12 in GT1 #HCV/#HIV Coinfected patients.1 HIV viral breakthrough" #NIAID #Liver14
Dr. Bourliere 96% GT1 cirrhotics achieve SVR12 w #harvoni. Adding RBV or longer rx to 24 wks ups SVR to 96+ from 90% in experienced #liver14
Dr. Dietrich presents TRIO SVR12 data. Again, some SVR increment with #sovaldi/#olysio in pre-#harvoni data #Liver14 http://t.co/bSVM6kCsvV
Payers will determine who gets #Harvoni. Let's hope criteria are better than what's in this piece. #HCV
http://onforb.es/1yW27c7 via @forbes
#Harvoni duration of therapy by category. Treatment experienced cirrhotics get 24 weeks. All others 8 or 12 #hcv http://t.co/ESjFPJ01NE
Highlight of #NewYorkTimes piece: concerning soundbytes from payers and #ESRX officials re: #Harvoni coverage #HCV
http://nyti.ms/112hj8B
Full #Harvoni package insert link for US Healthcare providers
www.gilead.com/~/media/Files/pdfs/medic...