We discuss that #enrichment of #CD8 #tcell #hypofunctional #states and their #diversity may depend on #quantitative & #qualitative determinants of #disease #development & #progression, during both #Infection (#burden vs. #duration) & #cancer (#antigens vs. #infiltration)! 3/6🧵

📢Happy to share our @natrevimmunol.bsky.social article; Result of #collaboration with @deadoc80.bsky.social @labliston.bsky.social & K Smith!
📑Read here: rdcu.be/ehm67
🔥Take🏠msg: Time to move away from narrow concept of #exhausted T cells to other #hypofunctional #states! 1/6🧵
@oncodaily.bsky.social

The conundrum of CD8+ T cell #trajectories in low antigenic #tumors: How to overcome a #hypofunctional state distinct from #antigen driven #exhaustion?

#Genes & #immunity @springernature.bsky.social
www.nature.com/articles/s41...