14/n 📌TIGIT expression in CD8+ T cells correlates w/NECTIN2+ myeloid cell abundance.
📌TIGIT expression in CD8+ T cells and NECTIN2+ myeloid cell proportion correlated w/ex vivo CD8+ T cell activation after tiragolumab.
📌TIGIT expression predicts ex vivo response to pembro+tira in #iPDCs.
13/n Last but not least, we subjected matched tumors from our #iPDCs to #t-CyCIF single-cell analysis, focusing on NECTIN2 and TIGIT expression. These are our key findings:
12/n Next, we wondered🤔: What happens if we treat chemo-exposed patient cells with immunotherapy vs. chemo-naive cells? Using #iPDCs (immune-competent patient-derived cultures), we showed that immunotherapy after chemo enhances CD8+ T-cell activity, unlocking new therapeutic potential💥.
