Xie, Lai & co-workers report a NHC-catalyzed #acylalkylation of #indoles for the construction of multisubstituted benzopyrrolizidinones. Broad scope, excellent diastereoselectivity, and late-stage functionalization of pharmaceutical skeletons🔬
#dearomatization #NHC

👉 buff.ly/YFbmsDq

Check out this efficient & environmentally friendly protocol by Yan, Cao & co-workers for synthesizing 1-(α-hydroxyindole)-o-carboranes✨ It's a #Friedel-Crafts reaction of #indoles with 1-formyl-o-carborane, no solvent or #Lewis acid needed🌱

👉 buff.ly/aK0A9Lu

Synergistic Photoredox and High-Spin Cobalt Cluster Dual Heterogeneous Catalysis: Vis-Light-Driven C(sp2)–H Bond Functionalization pubs.acs.org/doi/10.1021/... Zheng & co-workers @InorgChem #cobalt #HS #cluster #indoles #naphthoquinone #photocatalysis #SET #HAT #EPR #CHfunctnalizatn

Novel cross-feeding human gut microbes metabolizing tryptophan to indole-3-propionate Tryptophan-derived indoles produced by the gut microbiota, particularly indole-3-propionate (IPA), are key compounds associated with gastrointestinal balance and overall health. Reduced levels of I...

We identified new gut bacteria producing ILA and IPA, namely Lachnospira eligens and Enterocloster aldenensis. 🙌🥳 We also highlight the importance of cross-feeding and dietary fibers.
Huge thanks Janina Zünd and to all co-authors
#gut #microbiome #fibers #prebiotics #indoles doi.org/10.1080/1949...

Discovering the Gut-Brain Link: Implications for Mental Health Recent research has unearthed a fascinating connection between our gut microbes and anxiety relief, revealing that these tiny organisms produce compounds called indoles that significantly influence anxiety-related brain activity. This groundbreaking discovery paves the way for innovative therapies utilizing probiotics to enhance mental health and potentially alleviate anxiety symptoms. The Gut-Brain Connection: A Revolutionary Discovery A study conducted by scientists from Duke-NUS Medical School and the National Neuroscience Institute has shed light on a remarkable link between gut bacteria and anxiety-related behavior.

Discovering the Gut-Brain Link: Implications for Mental Health - #GutHealth #MentalHealth #AnxietyRelief #Probiotics #GutBrainConnection #Microbiome #Indoles #MentalWellbeing #AnxietyDisorders #PsychiatricResearch #InnovativeTherapies #Neuroscience #MentalHealthAwareness #PrecisionMedicine #HealthyL

Sidenote: what does it say about my life that I look at this #groundhog gif and contemplate its #microbiota metabolizing the 🥦 into #indoles?