📰New & Featured | A paper from #Nature suggests that #liver can be temporarily repurposed to restore immune signals that decline with age and enhance T-cell function in aged mice
🔸Delivering #mRNAs that encode #DLL1, #FLT3L and IL-7 to #hepatocytes expand #lymphoid progenitors

2️⃣ Advantages in Imaging & Controlling Single mRNAs:

• Single-mRNA sensitivity using 1×mNeonGreen fusions in live #imaging

• Track the localization & translation #mRNAs encoding cytoplasmic, nuclear, mitochondrial & secreted proteins

• Direct #mRNA localization by fusing dMCP to targeting signals

Multiple human enhancer RNAs contain long translated open reading frames A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Multiple human enhancer RNAs contain long translated open reading frames

"we have discovered that a fraction of human eRNAs can function as #mRNAs, revealing a new and unexpected role for these #transcripts."

genesdev.cshlp.org/content/earl...

To overcome this obstacle, I developed a Dynamic Time Warping approach to detect and analyze vaccine molecules using #DRS with high fidelity, enabling precise characterization of #polyA tails from #therapeutic #mRNAs. (4/n)

@mbarnalab.bsky.social others found ribosomes are heterogeneous, not uniform. Specialized ribosomes selectively translate specific #mRNAs, influencing cell fate, development & gene expression. This challenges the view of ribosomes as passive protein factories. www.science.org/doi/10.1126/...

Check out the latest issue of #BJAOpen.

Free to view articles on: #environmental #sustainability, #transfusion, #intubation, #SGAs, #prehospital, #ERAS, #mRNAs, #dexmedetomidine

Direct profiling of non-adenosines in poly(A) tails of endogenous and therapeutic mRNAs with Ninetails Nature Communications - Ninetails, a neural network that uses Nanopore Direct RNA sequencing data to identify non-A residues in mRNA poly(A) tails is presented. Particularly non-A of therapeutic,...

Nice! Congrats, Dziembowski lab!

Direct #profiling of #non-#adenosines in #poly(A) #tails of endogenous and therapeutic #mRNAs with Ninetails

Natalia Gumińska...Andrzej Dziembowski

rdcu.be/ed41t

This diagram representing a pollen grain features an annotated flow diagram to show how ACETYLATION LOWERS BINDING AFFINITY 3 stabilizes mRNA crucial to male fertility during heat stress at the reproductive stage in Arabidopsis.

How do crop plants protect their reproductive stage from heat stress? Ci et al. reveal a conserved mechanism by which ALBA3 safeguards male fertility under heat stress conditions by stabilizing specific #mRNAs crucial for #pollen function. doi.org/10.1111/jipb...
#PlantScience