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#macroautophagy
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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
2 months ago
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#Microglia-derived #nanovesicles is engineered to co-deliver CMA and #macroautophagy inducers across the BBB, synchronously restoring #proteostasis, clearing #βAmyloid, reducing #neuroinflammation, and rescuing cognition in #AlzheimersDisease models.

#STTT: doi.org/10.1038/s413...

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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
4 months ago
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Using the MiLi-FE method, this #STTT study developed AR@ENV—microglia-derived #Nanocarriers co-loaded with #Rapamycin & AR7—that promotes synchronized activation of #Macroautophagy & #CMA in #AlzheimersDisease therapy. #medsky

#OpenAccess: doi.org/10.1038/s413...

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IntAct
IntAct
@intact-ebi.bsky.social
9 months ago
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Excited to share the global proximity interactome in the Human Macroautophagy Pathway! (See: tinyurl.com/bdfaeztn)

Study uncovers novel role of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy #BrumellLab

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