Indeed! I managed to generate a decent online documentation for our #mesoSPIM project in 2h, something I was procrastinating for 5 years. Feels like magic.
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Hashtag
#mesoSPIM
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L’ #IERP et le #LuMin ont assemblé le premier #microscope français open source à illumination plane sélective, #MesoSPIM, conçu par l'Université de Zurich ➡️ www.ibisa.net/plateformes-... #Mifobio2025 #JST2025 #RMUI @inrae-france.bsky.social, ENS Paris-Saclay, @gdrimabio.bsky.social, #INBS EMERG'IN
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The #mesoSPIM symposium really opened my eyes to the power of open source hardware. I've highlighted some of the surprising outcomes in a new blog post:
How Open Source Microscopy is Solving the Funding Crisis: Insights from the mesoSPIM 10-Year Symposium
www.syglass.io/blog/how-ope...
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The #mesoSPIM community just celebrated 10 years of open-source light-sheet microscopy in Zürich! For #3DThursday, we're honoring Martina Schaettin & Fabian Voigt’s iconic 3D chick embryo dataset — a luminous benchmark for open science and shared discovery.
#Microscopy #Lightsheet #syGlass
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I have really neglected Bluesky. I'm going to try to add my backlog of adventures here now. To start, #mesoSPIM symposium in Zurich! Amazing conference, amazing people, amazing talks!
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Moritz in front of his poster presentation at the MesoSPIM Symposium in Zürich, Switzerland
Me in front of the ÖBB Nightjet sleeper train carriage that took me to Zürich and back. Surprisingly comfortable if you book the sleeper wagon with the nice beds!
This week I had the pleasure of attending the hashtag#MesoSPIM Symposium in Zürich, Switzerland - and what an experience it's been! Top-notch presentations, great posters and great chats with my fellow #lightsheet #microscopy and #tissueclearing nerds. You know […]
[Original post on mstdn.science]
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🚀 Nouvelle étape pour #MesoSPIM !
Après avoir monté le microscope à l'IERP de l'INRAE Jouy-en-Josas avec des physiciens de l'ENS Paris-Saclay 🤝, il devient transportable 🧳.
Rendez-vous à #MiFoBio & #JST_RmuI pour le découvrir en vrai 🔬✨
@inrae-france.bsky.social @gdrimabio.bsky.social
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Both are experienced clinical pathologists who are master users of #mesoSPIM and developed their own way of staining and clearing the most challenging tissues in their clinical practice. Want to learn which method will work best with your samples? Join us at #mesoSPIM2025 t.uzh.ch/1Ss
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One of the people I'm indebted the most for creating stunningly beautiful #mesoSPIM samples was Martina Schaettin - who tragically passed away in March this year. To honor her memory, Elkhan Yusifov created an award - submit your best #microscopy images & videos! www.linkedin.com/company/mart...
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📣We have opened our official User Forum: forum.image.sc/tag/mesospim
In this forum you can connect with 🔬developers and the image analysis experts. Ask your burning questions about the #mesoSPIM hardware, software, and image processing, or help the beginners to get started!
Tip: use project tags!
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mage presenting one of the speakers for the 10 Years of mesoSPIM symposium. Background of the image is a microscopy picture showing blood vessels in magenta and glial cells in cyan on a black field. On the left, the photo of the speaker is contained in a white-rimmed circle, on the right text reads: "Laura Baudis, University of Zurich, Switzerland" followed by the talk title "Probing dark matter and neutrinos with light sheet microscopy". On the bottom right reads "10 Years of mesoSPIM Symposium”
💥How can light-sheet help reveal dark matter?💥
Join Prof. Laura Baudis @lbaudis.bsky.social at #mesoSPIM Symposium, Oct 13–15 in Zurich or online, to see how light-sheet fluorescence microscopy 🔬 is used to image nuclear ☢️ recoil tracks to detect elusive particles!
Register now: t.uzh.ch/1Ss
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Organoids for #3DThursday! This is a tiny, lab-grown 3D model of a lung, meant to mimic the structure and function of real tissues.
🔬: #mesoSPIM #Lightsheet
🧫: Lung Organoid
🥼: Hei Ming Lai
🏛️: Illumos Ltd, www.nature.com/articles/s41...
🎬: syGlass.io
#SciComm #TissueEngineering #Organoid #syGlass
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🎉 Call for Abstracts! 🎉
Abstract deadline approaching! 10 years of #mesoSPIM initiative – join us at the symposium for talks, demos & posters on microscopy, tissue clearing, and data analysis!
📆 October 13-15, 2025
🗺️ Zurich, Switzerland, but also online.
www.adabd.uzh.ch/en/events/me...
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🎉 Call for Abstracts! 🎉
We’re celebrating 10 years of #mesoSPIM #opensource initiative – join us at the symposium for talks, demos & posters on open-source light-sheet microscopy, tissue clearing, and imaging!
Dates: October 13-15, 2025
Location: Zurich, Switzerland
Registration: ema.uzh.ch/R7YRN
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🔬 On June 6, we inaugurated the first #MesoSPIM in France at INRAE Jouy-en-Josas & ENS Paris-Saclay! A big thanks to @nvladimus.bsky.social , @mgarbelli.bsky.social ,Angeliki Vavladeli & all speakers and sponsors. Exciting step forward for #opensource imaging & interdisciplinary science! #microscopy
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Did you know that Universite Paris Saclay has its own Benchtop #mesoSPIM? Interdisciplinary team lead by @christellelangevin.bsky.social has built their own setup, the first in France, and organized an inauguration symposium! Cleared baby sturgeon or trout? They have it! French bioimaging is strong!
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For #3DThursday, whole mouse liver imaged with #mesoSPIM light sheet microscopy! Showing how structure meets function across the organ.
🥽: syGlass.io
🥼: Hei Ming Lai
📝: INSIHGT -> www.nature.com/articles/s41...
🏛️: Chinese University of Hong Kong
#LightSheet #SciComm #3DImaging #syGlass
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In 2021, I organized a #MiFoBio workshop with @Morgane BELLE, focused on tissue clearing & 3D lightsheet imaging of fly, lizards, spiders, axolotls, trout, ladybugs, and chicken embryos beyond mouse organ exercises! Arrival of the #MesoSPIM in my lab marks the beginning of a new chapter. Stay tuned!
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Want to learn about #mesoSPIM imaging initiative and network with microscopy and data analysis experts? Come to Paris-Saclay on June 6-th! Meet our team there! Registration is still open (and free)! mesospim-upas.sciencesconf.org
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🕘 6th of June 🗺️ Jouy-en-Josas, France 👉 https://mesospim-upas.sciencesconf.org/?lang=fr
Have you heard about #MesoSPIM microscopy platforms for imaging cleared tissue?
Join us to learn more about this #opensource #lightscheet device specific features, applications and discuss current challenges with experts in the field.
#3Dimaging #LightSheet #TissueClearing #AI #DataScience #R&D
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Save the date : official launch of the #MesoSPIM initiative at @univparissaclay.bsky.social - 6th of June - INRAE, Jouy en Josas. The event will bring together biologists, physicists, and mathematicians to foster #interdisciplinary collaborations.
👇https://mesospim-upas.sciencesconf.org/?lang=fr
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If you happen to need a #lightsheet #Microscope for cleared tissue on a budget: There is a Lavision Ultramicroscope on Ebay right now for $6.5k: www.ebay.com/itm/38806209... It's missing the laser unit and the PC but could serve as an excellent source of parts to build a #mesoSPIM 😉: mesospim.org
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### Performance :rocket: - implementation of time lapse function via script. See example script at `mesoSPIM/scripts/timelapse.py` for details. - images can now be displayed at full resolution during either live mode or acquisition, with no performance penalty. Deprecated config parameters: ``` python 'camera_display_live_subsampling': 2, 'camera_display_acquisition_subsampling': 2, ``` to enjoy full-resolution image in real time. The corresponding GUI elements for controlling the downsampling were removed. ### Bugfixes :bug: - duplication of sub-stacks while writing large H5 files (>0.5 TB) and freezing at the end of acquisition. Fixed by replacing signal/slot mechanism for CameraWindow image update to deque mechanism. Boosted performance and stability. - `MAX` projection is always on by default, if the dataset is asvaed in TIFF or RAW format. No need to check the box in the Image Processing Wizard. This generates maximum intensity projection as TIFF file for each stack in the acquisition list. - explicit initialization of the first raw in Acquisition Manager, to avoid undefined GUI widget states.
New release of #mesoSPIM control software! Major bug fixes and performance improvement. github.com/mesoSPIM/mes...
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Some good news: 3 new Benchtop #mesoSPIM are being built!
Scientists in China, USA, and Czech Republic are building the beautiful open-source beasts for their research.
South America, what are you waiting for? Australia? Greenland?
mesospim.org/setups/
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We are trying to materialize this idea with Benchtop #mesoSPIM. Make a robust framework and let people do crazy things with it.
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New experimental feature: timelapse for #mesoSPIM! Because why not? You can now image live specimen, such as developing organisms. Checkout this SW version at:
github.com/mesoSPIM/mes...
and let us know how it works for you. Be brave!
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In 2019, the #mesoSPIM and #ctASLM #lightsheet #Microscopy papers appeared back-to-back in @naturemethods.bsky.social - now Jinlong Lin, @zacsimile.bsky.social & @kevin-dean.bsky.social & Co introduce the MCT-ASLM - a chimera of both for smart multiscale #imaging!
www.biorxiv.org/content/10.1...
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"Zebrafish head"
In this captivating image, we can see the labeling of blood vessels in the head of a #zebrafish. Taken by Marko Pende on the #mesoSPIM in December 2022.
#flourescencefriday 🐟🎸 🧪🤝 #microscopy #fluorescentproteins #lightsheet
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Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!
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Did you know? Our Center for Microscopy and Image aAalysis (ZMB) website has detailed step-by-step instructions how to operate and troubleshoot your #mesoSPIM microscope. Prepared by @mgarbelli.bsky.social and José Maria Mateos Melero for users like you! zmb.dozuki.com/c/Lightsheet...
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