This review traces #precancer history and biology, spotlighting dysregulated TGF-β, p53, Wnt, PI3K, and MAPK pathways and a “soil degeneration” hypothesis favoring #microenvironmental dominance with dual-window interventions.

#OpenAccess in #STTT: doi.org/10.1038/s413...

#Research by Dakota R. Kamm et al. observes that #adipose stromal cells in the human rotator cuff are resistant to fibrotic #microenvironmental cues🔬 🔎

📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Microenvironmental determinants of endothelial cell heterogeneity - Nature Reviews Molecular Cell Biology Endothelial cells (ECs) undergo organ-specific specialization, driven by microenvironmental cues, to form patterned vascular networks. This article discusses mechanisms driving vascular inter-organ an...

📢 New #Review online!

Rafii and colleagues discuss specialisation of #endothelial cells, their inter- and intra-organ differences and how #microenvironmental factors determine endothelial cell heterogeneity.

🔗 go.nature.com/40WG4nt