Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates Neuron-specific splicing of Agrin by Nova RNA-binding proteins is essential for neuromuscular synapse formation via acetylcholine receptor clustering. This study shows that this RNA splicing pathway i...

🚨 New paper alert! 🚨

Our paper entitled: "Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates" is out now on @plosbiology.org !

journals.plos.org/plosbiology/...

#splicing #microexons #NMJ #Ciona

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🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social.

www.annualreviews.org/content/jour...

🚀 Check out our new review article “From Tiny Exons to Big Insights: The Expanding Field of #Microexons” now out in Annual Review of Genomics and Human Genetics!

doi.org/10.1146/annu...

Special thanks to @mirimiam.bsky.social, @crg.eu and @upf.edu!

NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas Aberrant splicing of microexons yields non-canonical surface receptors, such as the neuronal cell adhesion molecule (NRCAM) lacking amino acids encoded by exons 5 and 19. Sehgal et al. show that Δex5Δ...

3.5 years ago, we knew very little about #pediatric high-grade #glioma... our strengths were the working knowledge of #mRNA #splicing & #microexons and the ability to put together amazing teams of collaborators. Somehow, CureSearch for Children's Cancer had faith in us! www.cell.com/cell-reports...