Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells.

Now in #Science #Immunology: Hirahara lab reports activated #TH2 cells store LC-UFAs present in inflamed #lung within #lipid droplets. Subsequent catabolism via #microlipophagy induces ST2-hi effector & memory TH2 cell phenotypes, exacerbating #type2 #airway #inflammation!
#asthma #immunometabolism