Mucins in health and disease 15-18 June 2026, Ghent, Belgium Supported by VIB Training & Conferences

Registration is open for Mucins in Health and Disease! 15–18 June 2026, Ghent - Belgium

All info on:
www.vibconferences.be/events/mucin...

Travel awards available from @societymucosalimm.bsky.social and @mucosalimmunol.bsky.social

#Mucins #MucosalImmunology #Microbiome #Inflammation

🤔 How exactly do these mucins protect the BBB, and what other glycosylation pathways are involved?
🤔 Can we restore the glycocalyx to rejuvenate the ageing BBB?
🔗 By @carolynbertozzi.bskyverified.social et al: www.nature.com/articles/s41...
#Glycoproteins #Mucins #Ageing (4/12)

And finally Bruce Vallance who provided the valuable C. rodentium strains and helped identify critical experimental and conceptual gaps in the first drafts of the paper.

Thank you all!

(7/7)

#mucins #glycotime #Crohns #gut

Brendan Dolan helped us with high-res microscopy.
Liisa Arike ran the mass spectrometer.
Sara Thulin collected all the biopsies from the patients.

(6/n)

#mucins #glycotime #Crohns #gut

Molly Sivertsson worked diligently on the morphological analysis of tissues.

(5/n)

#mucins #glycotime #Crohns #gut

Fleur van de Koolwijk who worked on the microbial profiling.

(4/n)

#mucins #glycotime #Crohns #gut

Sofia Jäverfelt was in charge of the proteomics analysis.

(3/n)

#mucins #glycotime #Crohns #gut

Elena Layunta: first author who performed almost all the in vivo work including challenge protocols single-handedly!

(2/n)

#mucins #glycotime #Crohns #gut

Many folks in my lab and the Mucin Biology Groups contributed to this work. They’re not on this platform (yet), but they should be acknowledge for their hard work (1/n)

#mucins #glycotime #Crohns #gut

JCI Insight - MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease

🎄 Santa came early this year!🎄

We’re unwrapping an exciting discovery from our lab that reveals the critical role of the transmembrane mucin MUC17 in protecting the small intestine against bacterial challenges.

insight.jci.org/articles/vie...

#mucins #glycotime #Crohns #gut

The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes A dense glycocalyx, composed of the megaDalton-sized membrane mucin MUC17, coats the microvilli in the apical brush border of transporting intestinal epithelial cells, called enterocytes. The formatio...

How do massive megaDalton-sized transmembrane mucins reach the plasma membrane in intestinal epithelial cells? 🧐 Using proximity labeling, proteomics, and CRISPR KO, we uncovered key roles for MYO1B, MYO5B, and SNX27 in mucin transport. portlandpress.com/biochemj/art... #mucins #glycotime

It opens new perspectives on the functionalization of peculiar tRNA gene subsets for the synthesis of tandem repeat glycoproteins (i.e., #collagen, #fibroin, #mucins, etc.) in metazoan secretory systems for possible medical applications 🔬🥸⁉️

#aECM (apical extracellular matrix) is a subset of #ECMatrix that is distinct from stromal matrices or basement membranes. Anybody out there studying #mucins #ZPproteins #cuticle #glycocalyx #surfactant or the like? We need to find each other and start talking!

Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7 Human tissue surfaces are coated with mucins, a family of macromolecular sugar-laden proteins serving diverse functions from lubrication to the formation of selective biochemical barriers against harm...

We rang in #2022 by introducing a new member of the mucin (MUC) family, MUC3B that joined 3 already annotated membrane mucin genes clustered together on the human chromosome 7q22! journals.plos.org/plosone/arti... #mucins #glycotime