The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake - Parasites & Vectors Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previo...

Here we show that #nitisinone kills insecticide-resistant mosquitoes via cuticular uptake. Great work Zach Stavrou-Dowd, Lee Haines, & LITE. Thanks @gatesfoundation.bsky.social & @RoseTrees Trust @notredame.bsky.social @lstmnews.bsky.social parasitesandvectors.biomedcentral.com/articles/10....

The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake - Parasites & Vectors Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previo...

New paper out in Parasites & Vectors!
We show that nitisinone, a repurposed β-triketone, kills Anopheles gambiae via tarsal contact, even in pyrethroid-resistant strains.

doi.org/10.1186/s130...

#VectorBiology #Nitisinone #IRS #PublicHealth #malaria #mosquito

Safe human drug can poison mosquitoes Another potential mitigation for malaria...

www.thenakedscientists.com/articles/int... Many thanks to Chris Smith and the @NakeScientists for the short podcast about our recent publication on #Nitisinone & #Anopheles #mosquitoes

#Nitisinone already has regulatory approval for treating certain rare, inherited diseases. It works by blocking the production of a specific protein, which leads to reduced toxic disease byproducts in the human body. But when mosquitoes drink blood with nitisinone, they quickly die.

The drug in question is #nitisinone, and a proof-of-concept study led by a team from the Liverpool School of Tropical Medicine in the UK found that it could be deadly to mosquitoes at a low dose in human blood. The insects died within 12 hours.

Drug For Rare Disease Turns Human Blood Into Mosquito Poison Scientists have a radical new plan for controlling mosquito numbers and fighting malaria: lacing human blood with a drug that's poisonous for the insects, so sucking on this blood marks their last mea...

The drug #nitisinone, already approved in the US to treat metabolic disorders, can make human blood toxic to mosquitoes.

Female Anopheles gambiae #mosquitoes died within 12 hrs of consuming blood taken from 3 people who regularly take nitisinone.

www.sciencealert.com/drug-for-rar...

What if human blood were toxic to mosquitoes? A drug can make it so A single dose of the drug nitisinone could render a person’s blood lethal to mosquitoes for five days, modelling suggests.

🦟 "What if human blood were toxic to #mosquitoes? A drug can make it so.
A single dose of the drug #nitisinone could render a person’s blood lethal to #Anopheles mosquitoes for five days, modelling suggests." @nature.com
www.nature.com/articles/d41...

A new drug makes your blood toxic to mosquitoes – DW – 03/28/2025 A new drug that makes human blood poisonous to mosquitoes could be a vital new tool to fight malaria. The drug, called nitisinone, kills mosquitoes but is not toxic to humans.

A new drug makes your blood toxic to #mosquitoes

In Deutsche Welle Anna Last comments on 'promising' findings from a study by @notredame.bsky.social on the drug #Nitisinone, which could help to reduce mosquito numbers.🦟

www.dw.com/en/a-new-dru...

Rare Disease Drug Nitisinone Makes Human Blood Deadly to Mosquitoes | Newswise A study in Science Translational Medicine has identified a medication, Nitisinone, has the potential to suppress mosquito populations to help control malaria.

Rare Disease Drug Nitisinone Makes Human Blood Deadly to Mosquitoes
www.newswise.com/articles/rar...
#malaria #malariacontrol #mosquito #anophelesgambiae #nitisinone

Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine catabolism.

Glad this is finally out. Using pharmacokinetic modeling we show that #nitisinone, an FDA-approved drug 4 #Tyrosinemia & #Alkaptonuria, kills #Anopheles mosquitoes, outperforming #Ivermectin. Grateful to all primary author’s & fantastic collaborators!

www.science.org/doi/10.1126/...

In this work we show that #nitisinone kills both susceptible and insecticide-resistant Anopheles gambiae mosquitoes through cuticular absorption. Our findings support development of a new type of insecticides that specifically target the mosquito Tyr pathway without affecting insect pollinators.

Buy Nitisinone (Lasinone) Capsules Online At Lowest Prices. Nitisinone (Lasinone) capsule is used in the treatment of Hereditary Tyrosinemia Type 1. Buy Nitisinone Capsules Online At Lowest Prices. kindly Call/WhatsApp At +91 8130290915.

Nitisinone: Warnings & Precautions.

Nitisinone use has been linked to low platelet counts, often known as severe thrombocytopenia and leukopenia.
#Nitisinone #NitisinoneWarnings #NitisinonePrecautions #TyrosinemiaType1 #HT1Treatment #MedicationSafety
theindianpharma.com/nitisinone/