REVIEW: Nuclear receptor coregulator interactions: beyond the switch
By F. Nafrisha Cassim Bawa and Mitchell Lazar
➡️ https://genesdev.cshlp.org/content/40/3-4/146.full

University of Pennsylvania
#nuclearreceptor #transcription #ligand #coactivator #corepressor

RESEARCH PAPER: ERRγ impedes neuroendocrine prostate cancer development
By Li et al., and Vincent Giguère
➡️ https://genesdev.cshlp.org/content/40/3-4/160.abstract

Vincent Giguère
#prostatecancer #neuroendocrine #cancertherapeutics #nuclearreceptor

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: ERRγ impedes neuroendocrine prostate cancer development
By Li et al., and Vincent Giguère
➡️ genesdev.cshlp.org/content/early/2025/10/29...

#prostatecancer #neuroendocrine #cancertherapeutics #nuclearreceptor

Speaker Spotlight: Dr. Mitch Lazar @upenn.bsky.social
Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Aug 19-20, 2025, to hear from Mitch about #nuclearreceptor & circadian metabolism. Don’t miss his talk!

🔗 Register now – adiposebiology.com

#ABC2025 #Metabolism #ObesityResearch @mcgill.ca

PPAR Binding Strikes Again

Many thanks to @dereklowe.bsky.social for highlighting our recent study in @elife.bsky.social on synthetic ligand cobinding to the #nuclearreceptor PPARγ! I'm a long-time reader of the Blog, so this is quite a treat to be featured (in a positive light)! www.science.org/content/blog...

Well here we are on Bluesky! What/where's it happening, #prostatecancer, #nuclearreceptor #androgen #noncodingrna people?

Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ Commonly used covalent PPARγ inhibitors weaken, but do not block, binding of other ligands via an allosteric mechanism where ligands clash with a covalent ligand-induced transcriptionally repressive s...

Our new story is out in eLife! From the editorial assessment: "This landmark study elucidates the intricate structural mechanisms by which both covalent and non-covalent synthetic ligands can co-occupy the binding pocket of the #nuclearreceptor transcription factor PPARγ..." doi.org/10.7554/eLif...