Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease Despite widespread sex differences in prevalence and presentation of numerous illnesses affecting the human brain, there has been little focus on the effect of endocrine ageing. Most preclinical studi...

Sex steroids, such as #oestradiol, shape #female #brain health and risk for disease across the lifespan. Understanding the complex interplay of risk & protective factors on female brain health provides a neurological framework for vulnerability & resilience www.thelancet.com/journals/lan...
#EndoSky

In this article, Veronika A. Linhart, Lucas Dauga and Sara I. Liin (Department of Biomedical and Clinical Sciences, @liu.se) show how the inhibitory effects of #oestradiol on the #cardiac KV7.1/KCNE1 channel is species dependent.

📜 buff.ly/bmiiGnK

Transgender vrouwen hebben géén verhoogd risico op hartinfarct en beroerte | Amsterdam UMC In tegenstelling tot wat blijkt uit eerdere onderzoeken hebben transgender vrouwen die het hormoon oestradiol gebruiken voor hun transitie, géén verhoogd risico op een hartinfarct en een beroerte in vergelijking met mannen uit de algehele Nederlandse bevolking. Dit blijkt uit een grootschalige studie van Amsterdam UMC met data van ruim 4.000 transgender personen.

Transgender vrouwen die #oestradiol gebruiken, hebben géén verhoogd risico op een hartinfarct of beroerte, blijkt uit #onderzoek van Amsterdam UMC met data van 4.000 transgender personen. Lees meer 👇

Diane looking cute.

🏳️‍⚧️🩵🩵🩷🩷🤍🤍🩷🩷🩵🩵⚧️💉
I'm so excited to be returning to the endocrinologist in the morning for my next #oestradiol implant. I'm sure he'll be pleased to hear my name has been changed to reflect the #femme he helped to build. But is that really who haunts my dreams?
#transjoy #trans #gaht #oestrogen

Metabolic Messengers: oestradiol Oestradiol (E2), a steroid hormone derived from cholesterol, has long been recognized for its central role in female reproduction and pathobiology of menopause. However, accumulating evidence underscores a critical role for E2 in the regulation of systemic metabolism in both women and men. The metabolic actions of E2 are predominantly mediated by oestrogen receptor α (encoded by ESR1), a nuclear receptor with heritable expression patterns and tissue-specific transcript levels highly correlated with indices of metabolic health in both sexes. Here we provide an overview of the cell-specific actions of E2 and its receptors (α and β) in modulating key metabolic pathways. We contextualize these mechanistic preclinical studies with epidemiological data linking the menopausal transition to a marked rise of metabolic disease risk and provide evidence that E2 replacement mitigates this risk by preserving metabolic health. Hevener and Correa provide a comprehensive overview of the preclinical and clinical evidence showing the metabolic role of oestradiol and its receptors in both women and men.

METABOLIC MESSENGERS | A Hevener & S Correa (@dgsomucla.bsky.social) ‬ ‬‬

A comprehensive #overview of the preclinical and clinical evidence showing the metabolic role of #oestradiol and its receptors in both women and men 🧪 #Science

Read it here:

Metabolic Messengers: oestradiol - Nature Metabolism Hevener and Correa provide a comprehensive overview of the preclinical and clinical evidence showing the metabolic role of oestradiol and its receptors in both women and men.

METABOLIC MESSENGERS | A Hevener & S Correa @dgsomucla.bsky.social

A comprehensive #overview of the preclinical and clinical evidence showing the #metabolic role of #oestradiol and its #receptors in both women and men.

🧪

www.nature.com/articles/s42...

We spotlight #female #brain health across the lifespan by informing on the role of sex #steroids, particularly #oestradiol, on the female brain & on risk for diseases more prevalent in females, such as #depression & #Alzheimer's disease www.thelancet.com/journals/lan...

#EndoSky #WomensHealthSky

Diane looking appropriately curvy.

🏳️‍⚧️🩵🩵🩷🩷🤍🤍🩷🩷🩵🩵⚕️⚧️
The lovely effects of #gender #affirming #hormones are making things nice and curvy to the extent that my #vinegarsyndrome t-shirt is starting to look like a Mad Magazine fold-in😍

#trans #femme #gaht #hrt #oestradiol #estrogen #progesterone #transgender #transition #transjoy

We spotlight #female #brain health across the lifespan by informing on the role of sex #steroids, particularly #oestradiol, on the female brain & on risk for diseases more prevalent in females, such as #depression & #Alzheimer's disease thelancet.com/journals/lan...
#WomensHealth
#MedSky #EndoSky