PRESS RELEASE Fennec Pharmaceuticals Announces Clinical Research Collaboration with Tampa General Hospital Cancer Institute
We’re pleased to announce that the Tampa General Hospital Cancer Institute is initiating a study to evaluate real-world utility of PEDMARK® (sodium thiosulfate injection).
Learn more: bit.ly/3PfBj4N
#Ototoxicity #ChemoSideEffects #PatientOutcomes #ClinicalResearch #HearingHealth #CancerCare
The 5-year survival rate for all cancers combined is now approximately 69% due to major treatment advances such as platinum-based chemotherapy like cisplatin. However, an unfortunate side effect of cisplatin treatment is irreversible ototoxicity, or hearing loss.
With overall survival rates of all #cancers better than in previous decades, managing side effects of treatment - such as hearing loss from platinum-based #chemotherapy - is more important than ever.
Learn more about this common side effect:
fennecpharma.com/science/cispla
#Ototoxicity
Our mission is to help protect hearing for children, adolescents and young adults undergoing treatment for cancer with cisplatin-based chemotherapy, so they can look forward to a future filled with possibility.
#HearingHealth #Ototoxicity #ChemoSideEffects
"It just happened, and I had no idea. I would've, at the very least, like to know, like hey, you might lose your hearing. Having it told to me would definitely have been helpful. Like even just mentally preparing myself for something that might happen." -Jake Cancer survivor with cisplatin-induced hearing loss
Cisplatin-based chemotherapy is an effective treatment for #cancer, but some patients and survivors are left with permanent hearing loss, or #ototoxicity, that impacts their quality of life long after treatment ends.
#SoundsOfTheSeason #HearingHealth #ChemoSideEffects
"This indicates that the cells respond to distress signals much sooner than previously thought, raising intriguing questions about the underlying biological mechanisms driving these changes." bioengineer.org/chronic-otot... #ototoxicity #keeplistening
Image of a woman fitting headphones on a child. Text: Audiologists are essential in oncology care Before treatment -Establish a baseline record of hearing and balance During treatment -Administer periodic hearing tests to monitor for any changes, ringing in ears (tinnitus), or balance problems -Communicate with oncology team and suggest treatment options After treatment -Continue to monitor and evaluate
Not being able to fully hear or feeling dizzy can make daily activities challenging. 60 - 90% of #cancer patients develop #ototoxicity from cisplatin-based chemotherapy. Audiological monitoring is an essential component of #oncology care.
#HearingHealth #ComprehensiveCare
PRESS RELEASE Fennec Pharmaceuticals Announces Investigator-Sponsored Trial to be Conducted by City of Hope in Metastatic Testicular Germ Cell Tumors
Today we announced the planned initiation of an IST at @cityofhope.bsky.social to evaluate PEDMARK® (sodium thiosulfate injection) for preventing cisplatin-induced #ototoxicity (CIO) in adult men with stage II-III metastatic testicular germ cell tumors. bit.ly/3KvDPCd #CancerCare #ClinicalResearch
PRESS RELEASE Fennec Pharmaceuticals Announces Positive Topline Results from Investigator-Initiated Clinical Study of PEDMARK in Japan to Reduce Cisplatin-Induced Hearing Loss
We announced positive topline results from the investigator-initiated Phase 2/3 STS-J01 clinical trial of PEDMARK® (sodium thiosulfate injection) for the reduction of cisplatin-induced #ototoxicity in pediatric & #AYA patients w/ solid tumors in Japan. Read investors.fennecpharma.com/news-release...
Graphic titled: Oncology teams work together to provide care before, during, and after treatment. Graphic has four circles: Center image of child with otoscope being held close to his ear Top right image is a woman viewing an x-ray Bottom right image shows two HCPs Left image shows an occupational therapist with a child
Cisplatin is a cornerstone #chemotherapy but comes w/ a high risk of #ototoxicity. Children are more susceptible to the permanent hearing loss, but it impacts QoL for all patients -including #AYA.
Audiologists monitor for early signs & educate patients & HCPs on #hearing health.
#CancerCare
Oto-tox-icity Noun OTOTOXICITY refers to inner ear damage from exposure to certain drugs of chemicals, leading to hearing loss, tinnitus, and balance issues.
Platinum-based drugs, including cisplatin, are effective treatments for #cancer, but they may cause permanent hearing damage known as #ototoxicity.
To minimize the risk of long-term effects, auditory monitoring & assessments can help improve patient outcomes.
#ChemoSideEffects #ComprehensiveCare
Not all side effects of cancer treatment can be seen.
Cisplatin-induced #ototoxicity often remains after treatment ends.
During #InvisibleDisabilitiesWeek, we raise our voice to help ensure beating cancer doesn’t come at the cost of hearing.
#ChemoSideEffects #HearingLoss
Left side is an image of the ear point to the cochlea Right: Different impacts of hearing loss Speech and language skills Social-emotional development Academic performance Career potential Ability to live independently
#DYK When soundwaves travel through the inner ear, they stimulate sensory hair cells, triggering the nervous system to communicate with the brain.
Platinum-based treatments like cisplatin can cause #ototoxicity by damaging these cells & may result in irreversible #hearing loss.
#NHEW
Tinnitus is a common condition described as a ringing sound, but some people experience it as roaring or buzzing.
While #tinnitus is often the first sign of hearing loss, some medications – including cisplatin-based #chemotherapy – can cause #ototoxicity.
#HearingHealth #OncologySupport
Collaboration improves outcomes
Collaborative efforts between oncologists, audiologists, and researchers are vital to preventing #ototoxicity during cisplatin-based chemotherapy treatment.
By prioritizing hearing health, we can help prevent CIO to improve patient activities of daily living.
#Ototoxicity #OncologyCare 💛
Over two-thirds of childhood cancer survivors suffer from at least one severe health problem from their treatment or disease.
Survivors of childhood cancers face challenges resulting from therapies with toxic effects, like cisplatin-based chemotherapy.
Cancer treatments in the formative years can damage organs, affect learning, & require lifelong support.
#ChildhoodCancerAwarenessMonth #HearingLoss #Ototoxicity 💛
60-90% of patients treated with cisplatin may experience some form of hearing loss—a side effect known as #ototoxicity.
While cisplatin is a powerful cancer treatment, its impact on hearing can be life-altering.
#ChildhoodCancerAwarenessMonth #HearingLoss #OncologySupport #AYACancer #OncSky 💛
Celebrating 3 Years Pedmark
Today marks 3 years since the FDA approval of PEDMARK® (sodium thiosulfate injection). This anniversary reflects our fierce devotion to the fight against #ototoxicity in cancer patients who receive cisplatin-based chemotherapy.
#ChemoSideEffects #HearingLoss #CancerAwareness #AYA
Hearing loss affects a child’s ability to learn, communicate, & fully participate in life.
Treatments like cisplatin-based chemotherapy have significantly improved survival, but they carry a risk of irreversible hearing loss known as #ototoxicity.
Hearing loss affects a child’s ability to learn, communicate, & fully participate in life.
#ChildhoodCancerAwarenessMonth 💛
"Their study, published in Cancer Research Communications, reports that cisplatin causes inappropriate gene activation and protein interactions that lead to cell death in our outer ears." aacrjournals.org/cancerrescom... #ototoxicity #hearing #health #keeplistening
New in @drugsincontext.bsky.social
Platinum-induced #ototoxicity and hearing impairment in children and adolescents
Romano et al.
#drugsincontext #oncology #chemotherapy #childhoodcancer #platinum #MedSky #PharmSky
www.drugsincontext.com/platinum-ind...
We have a Hearing Loss LIVE! in Five podcast out today. Our topic: Ototoxicity - meds that may damage hearing. It doesn't happen often but it's good to be in the know.
youtu.be/ST4ufPXn_7E
#Ototoxicity #HearingLoss #HardOfHearing #ProtectYourHearing #GetInTheKnow #HearingLossLIVE
(podcast) Medicines can be toxic to the tissues of the ear, so why isn’t there more regulatory guidance to ensure patient safety? eureka.criver.com/podcast/are-you-listenin... #ototoxicity
