<italic toggle&#x3D;"yes">In Crystallo</italic> Photochemistry: Reimagining Synthetic Tractability with Transparent Single-Crystalline Flasks Expanding the boundaries of synthetic tractability ─ of what molecules can be synthesized and isolated ─ is an eternal challenge for synthetic chemists. The development of new synthetic methods and strategies enables the properties and potential functions of novel molecular targets to be experimentally evaluated. In the context of catalysis, predictable synthetic strategies are often available to access kinetically persistent intermediates such as catalyst resting states. In contrast, synthesis and characterization of the reactive intermediates are often not possible due to the fleeting lifetimes of these species. In crystallo photochemistry combines single-crystal matrix isolation with cryogenic photochemistry to enable reactive intermediates to be synthesized under conditions in which they are persistent and can be (crystallographically) characterized. This Outlook highlights key achievements of in crystallo photochemistry as well as discusses opportunities and challenges that confront realization of the potential of in crystallo synthesis to redefine the boundaries of synthetic tractability.

📢How #photocrystallography can help your research: "Merging cryogenic #photochemistry with #SingleCrystal reaction environments provides a #unique opportunity for molecular synthesis of reactive species." pubs.acs.org/doi/10.1021/... 🥳 #crystallography #education

Preparing for G0 visit! Showcasing in-house #Xray #crystallography #applications from Betley group: Crystallography usually provides direct, ultimate 3D structural insights like no other! 😀😀 doi.org/10.1021/jacs... doi.org/10.1021/acs....
#education #photocrystallography #AnomalousScattering

"isolating highly reactive #intermediates such as #metallonitrenoids ... is to generate them #InCrystallo and utilize the #CrystalMatrix to preserve the reactive motif. The
#GuidingQuestions allow students to reflect on what they have learned"😀😀 @japplcryst.iucr.org #photocrystallography #education

An Open-Shell FeIV Nitrido We report the photogeneration and characterization of an open-shell, terminal iron nitrido (EmL)Fe(N) using a sterically encumbered dipyrrin ligand environment. The Fe–N distance in the solid-state, zero-field 57Fe Mössbauer spectrum, and computational analysis are consistent with a triplet electronic ground state of the iron nitrido. Notably, the attenuation of Fe–N multiple bond character through occupying π*Fe–N enables (i) primary C(sp3)–H amination, (ii) H2 cleavage, (iii) aromatic C–C cleavage, and (iv) photocatalytic N-atom transfer reactivity. These modes of reactivity have not previously been observed in low-spin Fe(N) analogues.

Congratulations to Jeewhan from Betley Group at HarvardCCB: An #OpenShell FeIV Nitrido #Incrysallo #photocrystallography doi.org/10.1021/jacs... 🥳🥳 #crystallography #education

Light on for Christmas🥳🥳-- Yes, we can observe the #photocrystallography result after 365 nm excitation 🧐🧐
#crystallography #education

Trapping of the interstellar gas PN by reductive coupling. We monitored the light-induced linkage isomerization from Mo-PN to Mo-NP by SCXRD : Congrats Jorge Martinez! Smith group at @IUBChemistry #Photocrystallography #NSFChemMatCARS