Ally or adversary?

Insect #symbionts contribute to insect adaptation to protease inhibitors but impair their development and survival in suboptimal laboratory conditions

Results of #NCN Preludium by my former PhD, Beata
#beetle #proteaseinhibitors #insectmicrobes

www.nature.com/articles/s41...

Crowdsourcing rapidly identified chemotype scaffolds by merging fragment hits.

Strategies to support rapid optimization cycles.

Analysis of 367 complex crystal structures reveals hotspots for ligand engagement and a variety of ways to engage substrate recognition subpockets.

Iterative medicinal chemistry furnished an orally bioavailable inhibitor

MedSky🧪 #IDSky #Antiviral #Drugdelivery & #Drugdevelopment @aaas what’s next in #COVID Moonshot project & would noncovalent #SARSCoV2 main #proteaseinhibitors are the way to go ? Open science discovery of potent noncovalent #SARSCoV2 main protease inhibitors
www.science.org/doi/10.1126/...