Scientists report that #selenoprotein GPX3 mitigates #RenalIschemiaReperfusionInjury by suppressing #inflammation via #MAPKPathway inhibition and reduced #NADPH oxidase activity, elevating #IL10 and protecting #kidney tissue. #AcuteKidneyInjury

#OpenAccess: doi.org/10.1016/j.ge...

Selenoprotein GPX3 regulates NADPH oxidase expression by inhibiting the MAPK signaling pathway and thereby attenuating the inflammatory response in renal ischemia-reperfusion injury

This study shows that #selenoprotein GPX3 alleviates #inflammation during renal IRI by inhibiting the MAPK signaling pathway and reducing NADPH oxidase expression. #AcuteKidneyInjury #hypoxia #medsky

#OpenAccess: www.sciencedirect.co...

Dietary Selenium protect against #AorticMedialDenegeneration #AorticAneurysm #AorticDissection in🐭+BAPN

Selenium deficient diet < 0.05; adequate 0.2; supplemented 1 mg/kg

Doxycycline-sensitive ECM enzymes

#Ferroptosis GPX4 is a #Selenoprotein
#EJVES_ESVS 2024
www.sciencedirect.com/science/arti...